Getting off Wellbutrin

Posted by peggygris @peggygris, Apr 26, 2017

I have been on Wellbutrin for depression 20 years. It is no longer working. How do I go about stopping it with the least amount of withdrawal or side effects?

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Hello @peggygris, and welcome to Connect. We are happy that you made your way to Connect. We have a very supportive community of members, many of which have discussed taking wellbutrin, some with success and others with some side effects. Here on Connect, we are not able to give medical advice and always advise working closely with your medical provider when tapering medications.

Before I bring in a few members with experience with wellbutrin, would you mind sharing a bit more about your situation? Have you discussed your medications ineffectiveness with your provider? Has he or she recommended that you taper off the medication and try another medication?

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I RECENTLY started on Wellbutin – it really gets me accomplishing chores. What positive effects did u used to have?

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Took 2 years to get off venlafaxine counting beads ( for hot flashes) with the help of generic Wellbutrin 150 sr. Now 1 month of 150, 1 month of 150/100, one month of 100, one month of 100/75 ir, down to 75 ir and am sick – nauseous and fatigue. Went back to 100 mg and still sick 3weeks now. Please help. My doctor is no help.

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@mjfalk3

Took 2 years to get off venlafaxine counting beads ( for hot flashes) with the help of generic Wellbutrin 150 sr. Now 1 month of 150, 1 month of 150/100, one month of 100, one month of 100/75 ir, down to 75 ir and am sick – nauseous and fatigue. Went back to 100 mg and still sick 3weeks now. Please help. My doctor is no help.

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I’m so sick of hearing the doctors can’t help. This is a very serious issue. What can we do? These doctors have got to become educated on these drugs before prescribing.

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@mjfalk3

Took 2 years to get off venlafaxine counting beads ( for hot flashes) with the help of generic Wellbutrin 150 sr. Now 1 month of 150, 1 month of 150/100, one month of 100, one month of 100/75 ir, down to 75 ir and am sick – nauseous and fatigue. Went back to 100 mg and still sick 3weeks now. Please help. My doctor is no help.

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@mjfalk3. I am so sorry for your experience and your posting helped me in knowing I’m not the only one doctors won’t help. I was taking it so personally and wondering what was I doing wrong. Your comment lessened that feeling just a tiny bit in me.

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@mjfalk3

Took 2 years to get off venlafaxine counting beads ( for hot flashes) with the help of generic Wellbutrin 150 sr. Now 1 month of 150, 1 month of 150/100, one month of 100, one month of 100/75 ir, down to 75 ir and am sick – nauseous and fatigue. Went back to 100 mg and still sick 3weeks now. Please help. My doctor is no help.

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Hi @mjfalk3, welcome to Mayo Clinic Connect. Tapering off a drug like Wellbutrin requires patience. I'd like to bring a few other members into this discussion who have experience with Wellbutrin (bupropion) like @jimhd @stephee11 @enska @gamesjr @secretwhitepop.

In the meantime, I wonder if this article might offer anything useful for you:
– How Long Does Withdrawal From Wellbutrin Last? https://www.verywellmind.com/wellbutrin-withdrawal-symptoms-timeline-treatment-4176725

MJ, how are you sleeping?

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@colleenyoung

Hi @mjfalk3, welcome to Mayo Clinic Connect. Tapering off a drug like Wellbutrin requires patience. I'd like to bring a few other members into this discussion who have experience with Wellbutrin (bupropion) like @jimhd @stephee11 @enska @gamesjr @secretwhitepop.

In the meantime, I wonder if this article might offer anything useful for you:
– How Long Does Withdrawal From Wellbutrin Last? https://www.verywellmind.com/wellbutrin-withdrawal-symptoms-timeline-treatment-4176725

MJ, how are you sleeping?

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Thank you for the article but most of all for caring! Today I increased from 100sr to 150sr because I’m so sick. Praying this helps. Sleeping a few hours at a time with Melatonin and 3 drops of Cbd oil. Again, thank you for responding.

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@colleenyoung

Hi @mjfalk3, welcome to Mayo Clinic Connect. Tapering off a drug like Wellbutrin requires patience. I'd like to bring a few other members into this discussion who have experience with Wellbutrin (bupropion) like @jimhd @stephee11 @enska @gamesjr @secretwhitepop.

In the meantime, I wonder if this article might offer anything useful for you:
– How Long Does Withdrawal From Wellbutrin Last? https://www.verywellmind.com/wellbutrin-withdrawal-symptoms-timeline-treatment-4176725

MJ, how are you sleeping?

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May I suggest the book "The Anti-Depressant Solution" by Dr. Joseph Glenmullen. According to the book he has spent 30 years with Harvard Medicail School. He specializes in helping people slowly (and I do stress SLOWLY) discontinue taking drugs like Wellburtin. Please be sure to share information in the book with your doctor!

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@vfrifr

May I suggest the book "The Anti-Depressant Solution" by Dr. Joseph Glenmullen. According to the book he has spent 30 years with Harvard Medicail School. He specializes in helping people slowly (and I do stress SLOWLY) discontinue taking drugs like Wellburtin. Please be sure to share information in the book with your doctor!

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Thank you for the book recommendation, @vfrifr. You are right to underline "slowly". Do you have first-hand experience with tapering off a medication?

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@colleenyoung

Thank you for the book recommendation, @vfrifr. You are right to underline "slowly". Do you have first-hand experience with tapering off a medication?

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Yes, I am tapering off 25mg of Zoloft. I am one of the special 4% who expereinced severe heart palpitations. The first 3 tapers following doctors instruction were complete and total misery. (One taper put me in the hosptial for a day because I was so weak.) That only got me down to 7 mg. The doctors could not understand why I could not quite cold turkey. One even said it was the nocebo effect and I should discuss the issue with my psychotherapist to discuss just accepting the tapers. I did a considerable amount of reasearch on my own. Finding the book was only one piece of valuable information I found. Once I accepted (which is different that realized) that the tapering how much and when I taper is decided by my body, not the doctor, I relaxed about tapering. Thanks to the book, I was able to determine how much to taper, comfortably! The amount I taper is 0.4mg. My latest taper was from 6.0mg to 5.6mg. I started that taper on August 8th, 2021. Today (August 17th, 2021) my withdrawal effects are barely noticable.

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@bustrbrwn22

@mjfalk3. I am so sorry for your experience and your posting helped me in knowing I’m not the only one doctors won’t help. I was taking it so personally and wondering what was I doing wrong. Your comment lessened that feeling just a tiny bit in me.

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How are you doing now?

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@mjfalk3

How are you doing now?

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@mjfalk3. That is so thoughtful of you to ask. I’d prefer to PM you if that’s ok since I’m sure it’s very tiresome for people to hear my various autoimmune and neuropathy issues.

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