sandyjr
@sandyjr
@sandyjr
Posts: 116
Joined: Jan 23, 2019
Genetic testing...does anyone have the CHEK2 gene mutation
@shelleyc, am I understanding you correctly that radiation has been recommended for you? The role of radiation and CHEK2 is confusing. From what I understand (I'm not an oncologist), having radiation when someone has a germline mutations like BRCA1, BRCA2, CHEK2 and ATM may increase the risk of radiation-induced breast cancer. But if you get breast cancer, radiation treatment is still a viable treatment option. See this article:
– How to Manage Patients With Moderate-Risk Germline Mutations https://www.hematologyandoncology.net/archives/february-2018/how-to-manage-patients-with-moderate-risk-germline-mutations/
"Regarding local treatment, there is no evidence that any of the mutations other than TP53 should prevent a woman from having breast-conserving therapy that includes radiation."
I understand your concern and suggest you to ask your oncologist about it. I'd like to learn what you find out.
@tcennoc3303 Did you have radiation? I assume you're finished now. How are you doing?
No I did not have breast radiation yet because I think someone at MDAnderson needs to take a look at all of the information. I did have radiation RAI131 for the thyroid cancer. I feel like this radiation tipped the scales and that is why I am seeing the breast cancer. If I had never had that I would not be as concerned about doing more radiation. It also seems like some people with this Gene saw a second cancer within 10 years in the other breast. Even without this gene it seems that scatter radiation can do that. I just do not want to get 5 years down the road and be told I have another more serious breast cancer. Right now I have had two very treatable cancers. The next time I might not be so lucky.
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@colleenyoung
@sandyjr, I've been using Google and internet searches. But you're right. Most of the information comes from research studies and journals. There's not much info in layman's language unfortunately. The link in my post above is pretty comprehensive and not too hard to understand, not easy, but not too hard.
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