Anyone on Gemcitabine with Abraxane? How long? Effective?

My dad's been diagnosed in aug 2025 and we started with Nalirifox. After 4 chemos he started feeling more nauseous and weak. The doctor said as compared to other he has taken it pretty well and that as positive that the PET CT would reflect the same. However it was opposite. His ca19 when diagnosed was 22k which is not 50k. His ggt is 600 above. The doctor has advised for second line of treatment Gemcitabine and abraxane but only when GGT comes down to range of 200-300. We do not want to go for this. From the NGS report we found that there is capza2met found which is the main driver of his cancer. And the other genes are less reactive to chemo drugs. We are thinking that we skip the second like of treatment and start with Crizotinib which is the MET inhibitor tried and tested for MET driver cancer in lungs cancer. Has anyone tried or know someone who can share their experience or thoughts on this ? It would be if great help.

Hello.
I was diagnosed with Pancreatic cancer Dec 24 after going to ER for severe. jaundice. Found tumor in the head of the pancreas. Feb 25 started 5FU treatment for 12 - 2 week cycles . I did not tolerate it well at all with all kind of side-effects. Nausea, vomit diarrhea, fatigue. CT Pet should no progress in reducing tumor or CA19. So they chagrdvit to GA. Which is tolerated very well. 8 - 2 week cycles. Tomorrow shrank and CA went down. Proceeded to Wipple surgery which was a sucesss in removing the tumor, normal C A19. 3vweeks after surgery. No sign of metastases and levels normal. Until myb3 mo checkup. It has now metastases to liver. Stated on GA gain on Nov 13. Waiting on DNA of biopsy. Will go from.thete. hope I tolerate GA same as last time.

@hugo1313

What id GA?

Hi,
Gem Abraxane worked for me.
6 months. Then targeted radiation. Stable. 3 top oncologists have nothing to give me at the moment. Hope Kras inhibitors and vaccines will come to the forefront sooner than later.

I was diagnosed in Dec. 2024 and had 14 treatments ( 7 sessions of 2 weeks on, one week off) of Gemcitabine/Abraxane. I lost my hair, was very weak and tired and have minimal neuropathy in my feet, but tolerated it. The size of the tumor did not change but there may have been some killing of internal cells, possible necrotic tissue internally. I am also on Nivolumab immunotherapy for lung cancer, no mets from either. I was hoping to be a candidate for Whipple surgery, but my tumor was 4.2 x 4.8 cm. and needed to shrink away from a major vein and artery and reduce in size. The chemo did not accomplish that BUT I underwent 5 SBRT radiation treatments in September and it looks like it may have worked ( haven't spoken to the surgeon yet, just reading radiology report). I had the radiation done without using markers in order to be eligible for Nano-knife procedure. It's a relatively new procedure that not all hospitals have. I'm receiving treatment at CPMC San Francisco and as of last year has done more than 100 of them. It doesn't have a lot of history as far as survival rates, but the Whipple sounded pretty awful and the survival rates weren't great.
I am 78 years old and have been through 4 different cancers in 19 years. Hope your dad has good results. Oh, the oncologist and surgeon didn't think that another chemo drug would be effective hence the move to radiation. So far so good. Hope your dad has good results. Every one is different and reacts differently too.

@kakalena thankyou for explaning this. I wish you fast recovery and a lot of strength and happiness.

I think we will opt out of chemo as an option entirely. I am really looking forward for his infection and fever to stabilize now ( post celiac neurolysis and bile duct stent procedure ) so that we can start the target medication. Everyone is hopeful and positive that it will work. Hoping for the best now 😇

@shivany
Thanks for your good wishes. Amazingly, my tumor has shrunk about 50 % so I am now back in the possible Whipple surgery, depending on results of endoscopic ultrasound I'll be having tomorrow to verify that tumor has separated from artery and down to less than 50% contact with vein.. If it's a go, they want to do it ASAP because of scarring from radiation. If it's a no go, and I'm back on the nano-knife, then I have to wait another 3 months ( it has to be 6 months after final radiation treatment) It's one day at a time and there are lots of twists. I may be having chemo again after surgery which is sort of standard to catch any stray cells.