@bethieb I also want to drop my collagen peptides, but reading has convinced me to continue to ponder at least for now. Doctors are often out of date on the latest research because they have so many thing that they need to know.
Below is a meta-analysis research paper from less than a year ago. https://pmc.ncbi.nlm.nih.gov/articles/PMC12488437/
EXCERPT: "This meta-analysis shows that collagen peptide supplementation, especially when combined with calcium and vitamin D, significantly enhances bone mineral density and could make a contribution to preventing fracture in populations at risk, such as postmenopausal women. The impacts are greatest at the spine and femoral neck, with moderate to large standardized mean differences in studies. Supplementation with collagen also shows consistent effects on bone turnover markers ... "
And here is a university health site reference: https://www.uclahealth.org/news/article/collagen-peptides-may-be-beneficial-menopausal-bone-loss
EXCERPT: " ... Researchers found that a year of daily collagen peptides supplementation measurably increased bone mineral density in the lumbar spine and in the upper femur. The women also had higher levels of a blood biomarker that indicates bone formation. In a follow-up study four years later, the researchers reported continued benefits. It’s important to note that only a few small studies have been completed thus far, and that more research is needed for a definitive outcome... "
-------------------------
My take is that because a drug company cannot profit from a patent there is not enough money for a nice big expensive RCT trial. I don't consider the collagen peptides to be a cornerstone of my actions against OP (LIFTMOR type exercise and HRT are my key responses), so not sure what I will do when I next run out of collagen peptides, which I am now taking at half dose.
@bethieb I also want to drop my collagen peptides, but reading has convinced me to continue to ponder at least for now. Doctors are often out of date on the latest research because they have so many thing that they need to know.
Below is a meta-analysis research paper from less than a year ago. https://pmc.ncbi.nlm.nih.gov/articles/PMC12488437/
EXCERPT: "This meta-analysis shows that collagen peptide supplementation, especially when combined with calcium and vitamin D, significantly enhances bone mineral density and could make a contribution to preventing fracture in populations at risk, such as postmenopausal women. The impacts are greatest at the spine and femoral neck, with moderate to large standardized mean differences in studies. Supplementation with collagen also shows consistent effects on bone turnover markers ... "
And here is a university health site reference: https://www.uclahealth.org/news/article/collagen-peptides-may-be-beneficial-menopausal-bone-loss
EXCERPT: " ... Researchers found that a year of daily collagen peptides supplementation measurably increased bone mineral density in the lumbar spine and in the upper femur. The women also had higher levels of a blood biomarker that indicates bone formation. In a follow-up study four years later, the researchers reported continued benefits. It’s important to note that only a few small studies have been completed thus far, and that more research is needed for a definitive outcome... "
-------------------------
My take is that because a drug company cannot profit from a patent there is not enough money for a nice big expensive RCT trial. I don't consider the collagen peptides to be a cornerstone of my actions against OP (LIFTMOR type exercise and HRT are my key responses), so not sure what I will do when I next run out of collagen peptides, which I am now taking at half dose.
@bethieb I also want to drop my collagen peptides, but reading has convinced me to continue to ponder at least for now. Doctors are often out of date on the latest research because they have so many thing that they need to know.
Below is a meta-analysis research paper from less than a year ago. https://pmc.ncbi.nlm.nih.gov/articles/PMC12488437/
EXCERPT: "This meta-analysis shows that collagen peptide supplementation, especially when combined with calcium and vitamin D, significantly enhances bone mineral density and could make a contribution to preventing fracture in populations at risk, such as postmenopausal women. The impacts are greatest at the spine and femoral neck, with moderate to large standardized mean differences in studies. Supplementation with collagen also shows consistent effects on bone turnover markers ... "
And here is a university health site reference: https://www.uclahealth.org/news/article/collagen-peptides-may-be-beneficial-menopausal-bone-loss
EXCERPT: " ... Researchers found that a year of daily collagen peptides supplementation measurably increased bone mineral density in the lumbar spine and in the upper femur. The women also had higher levels of a blood biomarker that indicates bone formation. In a follow-up study four years later, the researchers reported continued benefits. It’s important to note that only a few small studies have been completed thus far, and that more research is needed for a definitive outcome... "
-------------------------
My take is that because a drug company cannot profit from a patent there is not enough money for a nice big expensive RCT trial. I don't consider the collagen peptides to be a cornerstone of my actions against OP (LIFTMOR type exercise and HRT are my key responses), so not sure what I will do when I next run out of collagen peptides, which I am now taking at half dose.
@kfhoz You make some very good points. I'll read the references you've sent, and I thank you so much for this information. I want to do whatever it takes to improve my bone health.
@daisy17 Fortibone brand of "Type 1 specific collagen peptides" was the collagen supplement used in at least one study, as below. But you can get "Type 1 specific collagen peptides" from other brands, and other studies used those other sources. See the reference to the meta-analysis in my other post.
Here is a study happened to use Fortibone, but they do not mention that brand in the conclusion section. https://pmc.ncbi.nlm.nih.gov/articles/PMC5793325/
EXCERPT: "5. Conclusions
In conclusion, the findings of this randomized, placebo-controlled trial demonstrate, that supplementation with 5 g of specific collagen peptides significantly increases bone mineral density of the lumbar spine and the femoral neck as well as blood levels of the bone marker, P1NP, in postmenopausal women with age-related decline in BMD."
I have used various brands over the years depending on prices or special deals or how much of the Collagen Peptides (CP) it contained. For example, the last bag I bought was Sparkle Wellness which contains 10g CP per serving of CP and that CP happens to be Fortibone. But the study referenced below used only 5g of CP, so I took only half the amount stated on the Sparkle bag.
An here is another of what I am coming to expect is typical result of "looks good, but more expensive research desired". https://pmc.ncbi.nlm.nih.gov/articles/PMC11842160/
EXCERPT: "Collagen supplementation demonstrates promising results. ... Future research should prioritize standardized protocols and consistent outcome measures."
------------------------------
So it boils down to potential benefit vs cost and risk of using CP supplements. I have not dug into CP as much as I have MK4. When is this osteoporosis journey ever easy?
@daisy17 Fortibone brand of "Type 1 specific collagen peptides" was the collagen supplement used in at least one study, as below. But you can get "Type 1 specific collagen peptides" from other brands, and other studies used those other sources. See the reference to the meta-analysis in my other post.
Here is a study happened to use Fortibone, but they do not mention that brand in the conclusion section. https://pmc.ncbi.nlm.nih.gov/articles/PMC5793325/
EXCERPT: "5. Conclusions
In conclusion, the findings of this randomized, placebo-controlled trial demonstrate, that supplementation with 5 g of specific collagen peptides significantly increases bone mineral density of the lumbar spine and the femoral neck as well as blood levels of the bone marker, P1NP, in postmenopausal women with age-related decline in BMD."
I have used various brands over the years depending on prices or special deals or how much of the Collagen Peptides (CP) it contained. For example, the last bag I bought was Sparkle Wellness which contains 10g CP per serving of CP and that CP happens to be Fortibone. But the study referenced below used only 5g of CP, so I took only half the amount stated on the Sparkle bag.
An here is another of what I am coming to expect is typical result of "looks good, but more expensive research desired". https://pmc.ncbi.nlm.nih.gov/articles/PMC11842160/
EXCERPT: "Collagen supplementation demonstrates promising results. ... Future research should prioritize standardized protocols and consistent outcome measures."
------------------------------
So it boils down to potential benefit vs cost and risk of using CP supplements. I have not dug into CP as much as I have MK4. When is this osteoporosis journey ever easy?
@kfhoz Study Report: https://pmc.ncbi.nlm.nih.gov/articles/PMC8441532/
After reading the study you referenced (see above) I have a different understanding of the results. To me, the results showed that Fortibone, called "specific collagen peptides" in the report, was compared to a different powder as a "placebo", and the results showed improvements in bone mineral density in the Fortibone group ("specific collagen peptides") whereas those taking the placebo showed decreases in bone mineral density.
From the report:
"3. Investigational product
The same bioactive collagen peptides (FORTIBONE®) from the main randomised control trial with a high safety (GRAS status) were used for this intervention."
"2.7. Protein Supplementation
For this study, a mixture of specific bioactive collagen peptides (SCP) with a mean molecular weight of approx. 5 kDa, derived from a complex multi-step hydrolysis of collagen, was used (FORTIBONE®, GELITA AG, Eberbach, Germany). The sachets containing 5 g SCP or placebo (maltodextrin, CARGILL, Paris, France) were identical in appearance and the products were equal in flavor and texture."
So, my takeaway is that the study found that women who took the SCP (Fortibone) showed increases in BMD, while the women who took a placebo showed decreases in BMD:
"The analysis showed that bone density significantly increased in the spine and the femoral neck after SCP treatment compared to placebo. In the SCP group, BMD increased by almost 3.0% in the spine and 6.7% in the femoral neck, whereas, in the same period, bone density decreased in the placebo group (−1.3% for spine and −1.0% in the femoral neck)."
The conclusion also stated the benefits of using "specific collagen peptides" -- which was Fortibone in the study.
"4. Discussion
The main outcome of this randomized, double-blinded and placebo-controlled study in postmenopausal women was that specific collagen peptides significantly increased bone mineral density (BMD) in both the lumbar spine and femoral neck. In contrast, no significant changes for these parameters were determined in the placebo group. Considering the decrease in BMD in the control group, subjects in the SCP group showed a 4.2% higher BMD in the spine and a 7.7% higher BMD in the femoral neck, suggesting a clinically relevant effect of the 12-month treatment with SCP ."
So, if I am going to take a collagen powder I will use a Fortibone product.
@kfhoz Study Report: https://pmc.ncbi.nlm.nih.gov/articles/PMC8441532/
After reading the study you referenced (see above) I have a different understanding of the results. To me, the results showed that Fortibone, called "specific collagen peptides" in the report, was compared to a different powder as a "placebo", and the results showed improvements in bone mineral density in the Fortibone group ("specific collagen peptides") whereas those taking the placebo showed decreases in bone mineral density.
From the report:
"3. Investigational product
The same bioactive collagen peptides (FORTIBONE®) from the main randomised control trial with a high safety (GRAS status) were used for this intervention."
"2.7. Protein Supplementation
For this study, a mixture of specific bioactive collagen peptides (SCP) with a mean molecular weight of approx. 5 kDa, derived from a complex multi-step hydrolysis of collagen, was used (FORTIBONE®, GELITA AG, Eberbach, Germany). The sachets containing 5 g SCP or placebo (maltodextrin, CARGILL, Paris, France) were identical in appearance and the products were equal in flavor and texture."
So, my takeaway is that the study found that women who took the SCP (Fortibone) showed increases in BMD, while the women who took a placebo showed decreases in BMD:
"The analysis showed that bone density significantly increased in the spine and the femoral neck after SCP treatment compared to placebo. In the SCP group, BMD increased by almost 3.0% in the spine and 6.7% in the femoral neck, whereas, in the same period, bone density decreased in the placebo group (−1.3% for spine and −1.0% in the femoral neck)."
The conclusion also stated the benefits of using "specific collagen peptides" -- which was Fortibone in the study.
"4. Discussion
The main outcome of this randomized, double-blinded and placebo-controlled study in postmenopausal women was that specific collagen peptides significantly increased bone mineral density (BMD) in both the lumbar spine and femoral neck. In contrast, no significant changes for these parameters were determined in the placebo group. Considering the decrease in BMD in the control group, subjects in the SCP group showed a 4.2% higher BMD in the spine and a 7.7% higher BMD in the femoral neck, suggesting a clinically relevant effect of the 12-month treatment with SCP ."
So, if I am going to take a collagen powder I will use a Fortibone product.
@daisy17 me too. I have been taking it. No results to report yet, but hey, why not? Throw everything at this osteoporosis. I don't believe it can hurt.
I'm a bit confused. I looked on Amazon, and all I can find are products that contain Fortibone along with other supposed collagen peptides like Fortigel and Verisol. Is there any place to get just Fortibone??
Connect
Connect
Like
Helpful
Hug
Intrest in Bone Health to improve my Dexascan.
I was taking it but my endo said the only thing that collagen has been proven to help might be hair improvement. I then stopped taking it.
-
Like -
Helpful -
Hug
1 Reaction@bethieb I also want to drop my collagen peptides, but reading has convinced me to continue to ponder at least for now. Doctors are often out of date on the latest research because they have so many thing that they need to know.
Below is a meta-analysis research paper from less than a year ago.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12488437/
EXCERPT: "This meta-analysis shows that collagen peptide supplementation, especially when combined with calcium and vitamin D, significantly enhances bone mineral density and could make a contribution to preventing fracture in populations at risk, such as postmenopausal women. The impacts are greatest at the spine and femoral neck, with moderate to large standardized mean differences in studies. Supplementation with collagen also shows consistent effects on bone turnover markers ... "
And here is a university health site reference:
https://www.uclahealth.org/news/article/collagen-peptides-may-be-beneficial-menopausal-bone-loss
EXCERPT: " ... Researchers found that a year of daily collagen peptides supplementation measurably increased bone mineral density in the lumbar spine and in the upper femur. The women also had higher levels of a blood biomarker that indicates bone formation. In a follow-up study four years later, the researchers reported continued benefits. It’s important to note that only a few small studies have been completed thus far, and that more research is needed for a definitive outcome... "
-------------------------
My take is that because a drug company cannot profit from a patent there is not enough money for a nice big expensive RCT trial. I don't consider the collagen peptides to be a cornerstone of my actions against OP (LIFTMOR type exercise and HRT are my key responses), so not sure what I will do when I next run out of collagen peptides, which I am now taking at half dose.
-
Like -
Helpful -
Hug
1 Reaction@kfhoz What brand of collagen are you taking? Have you heard of studies that recommend a specific type of collagen known as "Fortibone"?
@kfhoz You make some very good points. I'll read the references you've sent, and I thank you so much for this information. I want to do whatever it takes to improve my bone health.
-
Like -
Helpful -
Hug
1 Reaction@daisy17 Fortibone brand of "Type 1 specific collagen peptides" was the collagen supplement used in at least one study, as below. But you can get "Type 1 specific collagen peptides" from other brands, and other studies used those other sources. See the reference to the meta-analysis in my other post.
Here is a study happened to use Fortibone, but they do not mention that brand in the conclusion section.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5793325/
EXCERPT: "5. Conclusions
In conclusion, the findings of this randomized, placebo-controlled trial demonstrate, that supplementation with 5 g of specific collagen peptides significantly increases bone mineral density of the lumbar spine and the femoral neck as well as blood levels of the bone marker, P1NP, in postmenopausal women with age-related decline in BMD."
I have used various brands over the years depending on prices or special deals or how much of the Collagen Peptides (CP) it contained. For example, the last bag I bought was Sparkle Wellness which contains 10g CP per serving of CP and that CP happens to be Fortibone. But the study referenced below used only 5g of CP, so I took only half the amount stated on the Sparkle bag.
An here is another of what I am coming to expect is typical result of "looks good, but more expensive research desired".
https://pmc.ncbi.nlm.nih.gov/articles/PMC11842160/
EXCERPT: "Collagen supplementation demonstrates promising results. ... Future research should prioritize standardized protocols and consistent outcome measures."
------------------------------
So it boils down to potential benefit vs cost and risk of using CP supplements. I have not dug into CP as much as I have MK4. When is this osteoporosis journey ever easy?
-
Like -
Helpful -
Hug
2 ReactionsI understand it was the company that makes Fortibone paid for the research study.
So it’s a mystery to me?
@kfhoz Study Report: https://pmc.ncbi.nlm.nih.gov/articles/PMC8441532/
After reading the study you referenced (see above) I have a different understanding of the results. To me, the results showed that Fortibone, called "specific collagen peptides" in the report, was compared to a different powder as a "placebo", and the results showed improvements in bone mineral density in the Fortibone group ("specific collagen peptides") whereas those taking the placebo showed decreases in bone mineral density.
From the report:
"3. Investigational product
The same bioactive collagen peptides (FORTIBONE®) from the main randomised control trial with a high safety (GRAS status) were used for this intervention."
"2.7. Protein Supplementation
For this study, a mixture of specific bioactive collagen peptides (SCP) with a mean molecular weight of approx. 5 kDa, derived from a complex multi-step hydrolysis of collagen, was used (FORTIBONE®, GELITA AG, Eberbach, Germany). The sachets containing 5 g SCP or placebo (maltodextrin, CARGILL, Paris, France) were identical in appearance and the products were equal in flavor and texture."
So, my takeaway is that the study found that women who took the SCP (Fortibone) showed increases in BMD, while the women who took a placebo showed decreases in BMD:
"The analysis showed that bone density significantly increased in the spine and the femoral neck after SCP treatment compared to placebo. In the SCP group, BMD increased by almost 3.0% in the spine and 6.7% in the femoral neck, whereas, in the same period, bone density decreased in the placebo group (−1.3% for spine and −1.0% in the femoral neck)."
The conclusion also stated the benefits of using "specific collagen peptides" -- which was Fortibone in the study.
"4. Discussion
The main outcome of this randomized, double-blinded and placebo-controlled study in postmenopausal women was that specific collagen peptides significantly increased bone mineral density (BMD) in both the lumbar spine and femoral neck. In contrast, no significant changes for these parameters were determined in the placebo group. Considering the decrease in BMD in the control group, subjects in the SCP group showed a 4.2% higher BMD in the spine and a 7.7% higher BMD in the femoral neck, suggesting a clinically relevant effect of the 12-month treatment with SCP ."
So, if I am going to take a collagen powder I will use a Fortibone product.
-
Like -
Helpful -
Hug
1 Reaction@daisy17 me too. I have been taking it. No results to report yet, but hey, why not? Throw everything at this osteoporosis. I don't believe it can hurt.
-
Like -
Helpful -
Hug
2 ReactionsI'm a bit confused. I looked on Amazon, and all I can find are products that contain Fortibone along with other supposed collagen peptides like Fortigel and Verisol. Is there any place to get just Fortibone??
-
Like -
Helpful -
Hug
1 Reaction