Folic Acid for peripheral neuropathy

Posted by bigjohnscho @bigjohnscho, Jul 10 9:18am

I have been researching the use of Folic Acid for the treatment of peripheral neuropathy, but the dosage advised is so variable it’s impossible to determine. Has anyone tried this ? I would love to know their experience.

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Profile picture for John, Volunteer Mentor @johnbishop

Hi @ohkay2, Here's an article/reference that explains the difference.

"Recent data suggest the need to distinguish between naturally occurring folates and folic acid (FA), terms often mistaken and used interchangeably, both by practitioners and consumers, causing considerable confusion.1
In particular, 5-Methyltetrahydrofolate [methylfolate, 5-MTHF, or (6S)-5-MTHF], has been evaluated as a better alternative to folic-acid supplementation.2-5 In this article, I endeavor to clearly identify the difference between folic acid and folate, pointing out why Quatrefolic, the 5-MTHF glucosamine salt from Gnosis by Lesaffre, is the ideal choice, suitable for anyone but in particular for those expressing methylenetetrahydrofolatereductase (MTHFR) polymorphism, which is approximately 40% of the global population.6-10"
-- Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health
https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/

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John, thanks for the information on active folate. I am definitely going to review this with my neurologist.

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Profile picture for ohkay2 @ohkay2

Hi John,
When you say "methylfolate is the active form of folic acid", what does that mean?

I take 100mg folate daily.

I also take b-1 and b-6. I used to also take b-12 but my tests kept coming back showing my b-12 levels were too high.

Thanks!

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Ya gotta love the drug companies. Every drug production has side effects and in many cases PN was caused by cholesterol lowering drugs and that caused Type2 diabetes and that caused PN. I wonder how long the American Indians lived without drugs in their lives. I have a hunch that Buffalo meat and corn meals worked just fine.

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Profile picture for cit10jetjockey @cit10jetjockey

Ya gotta love the drug companies. Every drug production has side effects and in many cases PN was caused by cholesterol lowering drugs and that caused Type2 diabetes and that caused PN. I wonder how long the American Indians lived without drugs in their lives. I have a hunch that Buffalo meat and corn meals worked just fine.

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Imagine if they ate french fries.

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Profile picture for cit10jetjockey @cit10jetjockey

Ya gotta love the drug companies. Every drug production has side effects and in many cases PN was caused by cholesterol lowering drugs and that caused Type2 diabetes and that caused PN. I wonder how long the American Indians lived without drugs in their lives. I have a hunch that Buffalo meat and corn meals worked just fine.

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The Amerinds had the "3 Sisters". Squash, corn and beans which make a complete protein when eaten together. All the studies show that a plant based diet does the body more good but the Western diet seems to taste better. My favorite nutritionist coined the phrase "We are what we eat!" Words to live by.

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So which is better if you have SFPN? Active folate or folic acid? I’m confused per my condition.

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Profile picture for cit10jetjockey @cit10jetjockey

Ya gotta love the drug companies. Every drug production has side effects and in many cases PN was caused by cholesterol lowering drugs and that caused Type2 diabetes and that caused PN. I wonder how long the American Indians lived without drugs in their lives. I have a hunch that Buffalo meat and corn meals worked just fine.

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An almost complete meat diet has been a game changer in my symptoms.
I followed that trail Statin.elevated liver numbers Pre diabetes 😳 PN too late.
I ate well compared to most - sugar - junk has never been much in my diet. I was the quiona kale queen tons of veggies
The move towards diabetic was very unexpected. Gym girl. Serious work outs 20 years
Looking at food alternatives as meds- protein- meat. Seemed to be the only path open. It worked. A1c dropped. So did symptoms.
Damaged done to nerves.

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