Anyone taken Evenity (romosozumab) for Osteoporosis?

Thank you for the input. When you say a ‘break from meds might be possible’, you mean AFTER 1st Reclast yearly ? Trying to anticipate how soon after last Evenity I need to start new meds. I recall reading something to the effect of ‘one month + or - 7 days.
CTX is what??? I have done 24 hour calcium urine test, and CBC. but want to make sure that my endocrinologist requests all necessary bloodwork PRIOR to start of next drug. Thank you in advance for indulging my follow-up questions.

So glad to hear you are off to a positive start. Not unusual for back of arms to swell before the day is up. A bit uncomfortable sleeping on side, but for me it was gone by the morning. I’m a fan of behind the back of each arm.

Try the back of the arms. I’ve had shots at both UCLA & Penn Medicine - all injections done back of each arm.

My doc doesn't do CTX. It seems most endocrinologists don't do that kind of blood work. I believe P1NP is an indicator of bone building and CTX is a measure of bone turnover. But docs don't seem to use these,

Yes a break after one or possibly two Reclasts depending on testing. I wonder, at this point, if my doc will do CTX and P1NP or what my doc means by "monitoring"....maybe DEXA? I am getting a second opinon next week and will ask.

I was on Fosamax for some years then Reclast for 5 years. Was drug free for quite a few years until Dexa in 2021 showed severe osteoporosis. Started on Prolia. Between Jan 2022 and April 2023, I had 3 fractures due to osteoporosis each requiring surgery. Doctor said Prolia not effective and stated Tymlos last week. When I asked about treatment after Tymlos was told “will discuss later “. Did anyone take Tymlos prior to Evenity?

I hope you continue to have minimal side effects. I go tomorrow for my 5th set of injections. After my 4th set, I started to feel some other side effects that I am now not happy with. I will discuss this tomorrow when I see the MD. I also want him to order some blood work that I feel is needed based on the book " Good Bones" which I feel everyone should read.

I encourage you to read " Great Bones" by Dr McCormick, he goes into detail which lab work should be done prior to starting any medication. It is a great resource for anyone who has Osteoporosis.

I have no idea about the other drugs. I can only tell you that my Physician said Reclast and Bosphosphonate stay in your bones for a long time, that why I have the dental problems and dificulty having extractions and implants.

@kay44 how long were you on a bisphosphonate/Reclast and what dental problems?

Dentists are really afraid to do extractions, implants etc. but the serious issues, my doc said, are mainly with cancer patients on high doses and/or folks on them for a long time. Prolia and Reclast and other bisphosphonates are all anti-resorptives and I was told Evenity is too for the last half of treatment.

Having on infusion of Reclast after a bone-builder "locks in" gains and because it stays around for awhile, we might be able to take a break in meds. So that is a positive side to the long lasting effect of Reclast.

Right- I keep reading about the very long half life of Reclast- that it stays in your body virtually forever.
I read one explanation that as it’s deposited in your bones, the osteoclasts do their thing ( breaking down bone) thus releasing the Reclast.
So I’m wondering why we’re advised to take it every year for 3-5 years???

I also read another study that said a half dose, as well as every 18-24 months is as effective as usual administration.

* I’d post a link but the studies don’t allow it somehow. If interested I can try to post that.