Endometerial cancer with essential throbocythemia (ET) Jak 2 mutation

@1995victoria, I added your question to both the Blood Cancer & Disorders support group as well as the Gynecologic Cancers support group. I believe this may be the research you're referring to:
- JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α https://pmc.ncbi.nlm.nih.gov/articles/PMC11669642/

Is your endometrial cancer diagnosis recent? What treatment have you had or will be having?

I'm thinking if I knew there was this Jak2 and endo cancer connection, I would have been monitoring my endometrial lining during the 5 years I've had ET Jak2. Maybe could have caught cancer earlier in its invasion. I wonder what else Jak2 mutation can be involved in. I thought it was only ET.

@colleenyoung Diagnosed last Wednesday, meeting with Doctor next Wed to discuss next steps.

@1995victoria, those are all good questions to ask at your next appointment with oncology. I would also ask if the JAK2 mutation influences which treatment options are best for you.

What's the research study that you're referring to?

@1995victoria I thought I would tag our original poster for a response to the question by @val64: What's the research study that you're referring to?

That paper Colleen cited doesn't have anything to do with ET or PV and does not at all imply that having ET would increase risk of endometrial cancer. Just because various cancers may have JAK2 mutations doesn't mean there's any causal relationship with JAK2 V617F MPNs.

@val64 - JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α https://pmc.ncbi.nlm.nih.gov/articles/PMC11669642/

ET with Jak2 mutation......

@1995victoria

Based on this, there's no reason to think that your (or anyone else's) endometrial cancer has anything to do with your JAK2 mutated ET.

The V617F mutation occurred in one of the stem cells that makes blood cells. It's an activating mutation.

JAK2 inactivating mutations occur rarely in endometrial cancers, which are derived from cells of the lining of the uterus. They are completely different mutations, and it's very unlikely that your endometrial cancer even has one.