Elevated ssdna

I know it is sometimes scary when you read the lab test results before you've had a chance to discuss them with your doctor. I have fallen into that trap a few times and get a little anxious until I can discuss the results with my doctor who can put things into perspective. Here's some information I found on the ENA panel that may explain it a little.

"No one result on an ENA test means you have a specific disease, like lupus. For instance, people with Sjögren’s syndrome are often positive for anti-SSA and anti-SSB antibodies, but they can also be positive in someone with lupus or other conditions. Your provider will look at your ENA panel, your symptoms and other test results to make a diagnosis."
-- ENA Panel: https://my.clevelandclinic.org/health/diagnostics/ena-panel

Have you had a chance to discuss the results with your doctor yet?

ssdna is single stranded dna. Elevation in Panel 9 is associated with several different autoimmune conditions. You are wise to understand your labs before you consultation with your doctor. You'll have better questions and they will provide better answers. This is the best place to ask. You may get better responses from connecters with experience if you also describe your symptoms.
John's point is well taken, except that you don't seem to distressed, just intelligent.

FWIW here’s a 2002 discussion of clinical decision making with IgG antibodies to ssDNA
https://www.researchgate.net/publication/257612519_Clinical_value_of_anti-ssDNA_denatured_DNA_autoantibody_test

No, not yet. I've had mildly elevated DSDNA before but this is new. Thank you

Thank you. Scleroderma/ systematic sclerosis, RA factor, Complements(lupus)), proteins, negative.
I have chronic inflammation all over body including hands, face, ears, feet, inner nose gums, lichens sclerosus. Hand pain and dropping things. No carpel tunnel. Diagnosed with polyneuropathy and reactivations of ebstein barr virus. Heat intolerant, low grade fevers, neck/back pain, stiffness, mobility issues. Frequent infections, brain fog, bowel and bladder problems, hair loss, extreme fatigue at times, balance issues, history of falling, 1 grand mal seizure. Edema in lower legs and feet, especially walking or warm weather. No diabetes. Gerd, gastritis, high blood pressure. Tinnitus without hearing loss.

Wow. My Primary Care Physician thinks I have Vasculitis - PMR. Based on symptoms and elevated ESR, +ANA, high CRP. He started me on 15 mg prednisone which helped tremendously with symptoms in about 4 days. He referred me to a rheumatologist. I saw the rheumatologist 22 days after being on prednisone. By then, I’d started having headaches & feeling faint/dizzy if I bent down or upon standing up. I was also hearing buzzing or whooshing (my heartbeat). He did another blood test which shows ssDNA at 420 but said the other tests which would indicate lupus are in normal range. He also had a temporal artery biopsy - which was normal. But the biopsy was done after I’d been on prednisone a month & I was using prednisolone drops from a retinal surgery a month before, so he said it could be a false biopsy. I’ve seen the rheumatologist twice & I feel like I have no answers, no explanations. I quit taking the prednisone this week because of the feeling like I’m going to faint - it’s like someone is squeezing my throat, my vision narrows & I have to grab something to stay upright. I’m afraid to drive, but I have to. Rheumy says that’s not from vasculitis & I should see a neurologist but makes no recommendation. I’m beyond frustrated. He also says he doesn’t know what my diagnosis is but wants me to come back in 2 weeks. I don’t see the point in going back to him. I’m thankful that the pain, stiffness, in joints: neck, shoulders, hips, knees, ankles, and wrists is better. I’m thankful to my Primary. I just wish someone would explain what has happened to me - this pain in joints started in February, but the headaches & feeling like I’m going to pass out started in May. Any suggestions would be gratefully accepted.

Oh, I will say that I found meditating more often seems to help.

Was it your "anti-ssDNA antibodies" that were high? If so, that can point to some kidney or liver dysfunction such as chronic hepatitis or the renal complications of diabetes.

Ya, if labs, etc. arent cookie cutter in terms of a diagnosis, doctors seem to get turned off real fast. Some miss things, that's why other opinions are necessary.
If he thinks you should see a Neurologist, you need to ask him to refer you to one. I'd give it a try.