Has anyone been prescribed EB-N5?

Posted by Ray Kemble @ray666, Jun 30, 2023

Has anyone been prescribed EB-N5? I see there was a discussion of this supplement before, but it dates back to 2018. I received a message this morning from my neurologist saying he'd like me to begin taking EB-N5. Unfortunately, he's not in the office today, so I'm not able to ask him what I might expect from EB-N5. If any of you have used this supplement, I'd love to know what results, if any, you had.

Ray (@ray666)

Interested in more discussions like this? Go to the Neuropathy Support Group.

@zav

Thanks. I am going to call the company as well. Just need to be safe and not cause more harm.

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I’m sure you’ll be thorough. As an aside, 3 weeks ago I replenished my OTC Magnesium supplements - I always just settle for whatever Buy 1 Get 1 Free I see. I didn’t pay attention that I bought 400mg capsules instead of 200mg. RDA is only 250-300mg and I know I get some (if not enough) from diet, but take the supplement to help PN and regularity. Anyway, in recent days I realized I must be overdosing on Mg; I was having concerning increase in muscle/nerve weakness and twitching. As well as GI changes. Dr. Google lists those as excess Mg symptoms, even though it doesn’t seem like much. I wish I’d paid attention sooner and had not changed my dosage (hindsight is always great) I just stopped it last night and hope I return to my “normal “ soon to confirm.
I have no doubt you’ll be monitoring everything as you try this supplement and it’s good to share with everyone else looking for quality of life maintenance or improvement. I have low blood sugar, which is one reason my doctor has wanted me to stay away from some regimes.

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@johnbishop

It appears to be another manufacturer of their own proprietary blend of ingredients for neuropathy. I haven't seen any research trials on their products but some of the ingredients can be found in neuropathy research that they are helpful. Here's what EB-N5 actually contains from their website: https://ebmmedical.com/medical-foods/
EB-N5® INGREDIENTS
L-methylfolate calcium 6 mg
Methylcobalamin 4 mg
Pyridoxal 5′-phosphate 70 mg
Alpha-lipoic acid 600 mg
Cholecalciferol 5000 IU

So then begs the question - can you buy the separate ingredients cheaper yourself if you think EB-N5 might help. Just being the Devil's advocate here 🙃

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Isn't paradoxal 5 the same as b6? I have read too much b6 can be toxic and cause neuropathy. This seems like a large dose of b6.

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@ray666

Hi, John

That's my question, too: Can I purchase the ingredients separately and save money? I'm going to look into that. I've already purchased the manufacturer's three-month supply, but after that … ? I'd like to know.

Ray

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Pyriodoxal 5 is b6. That is a very high dose of b6 which can be toxic and cause neuropathy even at smaller doses. European counties have actually limited amount of b6 in supplements to 10mg due to it being a neurotoxin. Sometimes it helps numb pain but that is bc it is killing nerves so in long run not good.

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@dbeshears1

I’m sure you’ll be thorough. As an aside, 3 weeks ago I replenished my OTC Magnesium supplements - I always just settle for whatever Buy 1 Get 1 Free I see. I didn’t pay attention that I bought 400mg capsules instead of 200mg. RDA is only 250-300mg and I know I get some (if not enough) from diet, but take the supplement to help PN and regularity. Anyway, in recent days I realized I must be overdosing on Mg; I was having concerning increase in muscle/nerve weakness and twitching. As well as GI changes. Dr. Google lists those as excess Mg symptoms, even though it doesn’t seem like much. I wish I’d paid attention sooner and had not changed my dosage (hindsight is always great) I just stopped it last night and hope I return to my “normal “ soon to confirm.
I have no doubt you’ll be monitoring everything as you try this supplement and it’s good to share with everyone else looking for quality of life maintenance or improvement. I have low blood sugar, which is one reason my doctor has wanted me to stay away from some regimes.

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Good morning, Debbie (@dbeshears1), bb0753 (@bb0753), zav (@zav)

Let's pool here what we learned about B6. I'd heard that B6 from supplements came with a caution, but until getting my doctor's suggestion that I try EB-N5, I had paid it little mind.

On its website, NIH presents two side-by-side fact sheets on B6, one for professionals and the other for consumers. The consumers' fact sheet, under "Can vitamin B6 be harmful?" says, "People almost never get too much vitamin B6 from food or beverages. But taking high amounts of vitamin B6 from supplements for a year or longer can cause severe nerve damage, leading people to lose control of their bodily movements. The symptoms usually stop when they stop taking the supplements."

I'll spend a little time later today looking into this. My doctor may be taking time off for the extended Fourth holiday, but I try calling him anyway.

Cheers, everyone!
Ray (@ray666)

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@ray666

Good morning, Debbie (@dbeshears1), bb0753 (@bb0753), zav (@zav)

Let's pool here what we learned about B6. I'd heard that B6 from supplements came with a caution, but until getting my doctor's suggestion that I try EB-N5, I had paid it little mind.

On its website, NIH presents two side-by-side fact sheets on B6, one for professionals and the other for consumers. The consumers' fact sheet, under "Can vitamin B6 be harmful?" says, "People almost never get too much vitamin B6 from food or beverages. But taking high amounts of vitamin B6 from supplements for a year or longer can cause severe nerve damage, leading people to lose control of their bodily movements. The symptoms usually stop when they stop taking the supplements."

I'll spend a little time later today looking into this. My doctor may be taking time off for the extended Fourth holiday, but I try calling him anyway.

Cheers, everyone!
Ray (@ray666)

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B6 is a big reason I stay away from all energy drinks.

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Good morning, John (@johnbishop)

Yikes! I hadn't thought about energy drinks, although I rarely drink one. What this thread has me thinking about, though, as I wait for USPS to deliver my EB-N5, are the other supplements I've been taking for a long, long time as part of my daily regimen, things like Centrum Silver, a B6 pill, B-Complex, others too (?). I'm going to have to check their labels to see how much B6 I'm already getting from supplements. Surely my doctor would be thinking about this, wouldn't you think? I suspect he is; he's very thorough. Nevertheless, it's conversations like this that remind me that, as a patient, I must never completely leave the bridge and let someone else steer the ship of my health all by himself.

Cheers!
Ray (@ray666)

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@ray666

Good morning, Debbie (@dbeshears1), bb0753 (@bb0753), zav (@zav)

Let's pool here what we learned about B6. I'd heard that B6 from supplements came with a caution, but until getting my doctor's suggestion that I try EB-N5, I had paid it little mind.

On its website, NIH presents two side-by-side fact sheets on B6, one for professionals and the other for consumers. The consumers' fact sheet, under "Can vitamin B6 be harmful?" says, "People almost never get too much vitamin B6 from food or beverages. But taking high amounts of vitamin B6 from supplements for a year or longer can cause severe nerve damage, leading people to lose control of their bodily movements. The symptoms usually stop when they stop taking the supplements."

I'll spend a little time later today looking into this. My doctor may be taking time off for the extended Fourth holiday, but I try calling him anyway.

Cheers, everyone!
Ray (@ray666)

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Yes, many US doctors do not seem to read updated info. Google info and you can find there has been many news articles especially in Australia of dangers of b6 supplements many which have been recommended by doctors or naturopath. Many have found idiopathic neuropathy has actually been result of long term supplemention as low as 20mg.. best wishes

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@ray666

Good morning, Debbie (@dbeshears1), bb0753 (@bb0753), zav (@zav)

Let's pool here what we learned about B6. I'd heard that B6 from supplements came with a caution, but until getting my doctor's suggestion that I try EB-N5, I had paid it little mind.

On its website, NIH presents two side-by-side fact sheets on B6, one for professionals and the other for consumers. The consumers' fact sheet, under "Can vitamin B6 be harmful?" says, "People almost never get too much vitamin B6 from food or beverages. But taking high amounts of vitamin B6 from supplements for a year or longer can cause severe nerve damage, leading people to lose control of their bodily movements. The symptoms usually stop when they stop taking the supplements."

I'll spend a little time later today looking into this. My doctor may be taking time off for the extended Fourth holiday, but I try calling him anyway.

Cheers, everyone!
Ray (@ray666)

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I don't know a lot about B6, except when I got this PN 7 years ago, they said to make sure B12 stayed good, and a little extra didn't hurt. So I took a B Complex vitamin to get all the B's. My primary Neurologist sent me for a PN consult to 2 medical universities early on, and by the time I got to the Duke appointment, my B6 was higher than standard. The doc first thought she found my "cause" but all of my B's were fine when the PN started 4 months earlier, it only went up because I intentionally added the daily supplement. So she told me to stop that, and only add trace amounts of B6 if it was part of another vitamin (like One A Day) but to not try to increase B6.

REPLY
@ray666

Good morning, John (@johnbishop)

Yikes! I hadn't thought about energy drinks, although I rarely drink one. What this thread has me thinking about, though, as I wait for USPS to deliver my EB-N5, are the other supplements I've been taking for a long, long time as part of my daily regimen, things like Centrum Silver, a B6 pill, B-Complex, others too (?). I'm going to have to check their labels to see how much B6 I'm already getting from supplements. Surely my doctor would be thinking about this, wouldn't you think? I suspect he is; he's very thorough. Nevertheless, it's conversations like this that remind me that, as a patient, I must never completely leave the bridge and let someone else steer the ship of my health all by himself.

Cheers!
Ray (@ray666)

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Always good to ask. My new PCP recently ordered (via my mail order) a statin for cholesterol, one that my PCP 7 years ago stopped and that my last PCP didn't think was ideal for my barely high cholesterol. Last week I asked my new cardiologist about it and he said HELL NO, my overall heart risk factor from cholesterol (or something or other) was only 8%, so not to do it. I feel I have offended some doctors for questioning Heart/Neuropathy/Liver or drug interaction risks, but I've had several reversal of decisions, or admissions they need to get another opinion because they weren't sure, so I think we have to help them (and mostly ourselves) out sometimes since we one of the very many patients they have and we know the time constraints they have that adds risk to them not being able to do the deep dive on us for every (sometimes) quick decision or idea they may have. We're partners with them, not adversaries.

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@dbeshears1

I don't know a lot about B6, except when I got this PN 7 years ago, they said to make sure B12 stayed good, and a little extra didn't hurt. So I took a B Complex vitamin to get all the B's. My primary Neurologist sent me for a PN consult to 2 medical universities early on, and by the time I got to the Duke appointment, my B6 was higher than standard. The doc first thought she found my "cause" but all of my B's were fine when the PN started 4 months earlier, it only went up because I intentionally added the daily supplement. So she told me to stop that, and only add trace amounts of B6 if it was part of another vitamin (like One A Day) but to not try to increase B6.

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Hi, again, Debbie (@dbeshears1), bb0753 (@bb0753)

What you have to say about your experience with B6 is really telling. As far as I know (and I have copies on file), none of my past lab reports have indicated a problem ("out of range" with my B6. But going forward from today? Sounds like something to pay extra attention to.

My EB-N5 arrived today. I popped my first capsule, and so far I've not shown any signs of shape-shifting. LOL 🙂

(In light of all of our B6 posts, I did skip my B-Complex today.)

Ray (@ray666)

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