DVRd quadruple therapy for myeloma: Nervous about side effects

Posted by okiebon @okiebon, Apr 20 9:34pm

I’m starting DVRD quad therapy for MM later this week. Somewhat nervous on side effects although I know they vary by individual. Any insight/advice?

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Colleen Young, Connect Director | @colleenyoung | Apr 26 1:35pm

@okiebon, I'm tagging a few members like @cyndielm @sallik74 @donna195 @wesleym @itlooksunny, who may have experience with DVRd (Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone) quadruplet therapy to share with you.

@okiebon, did you have your first treatment? How did it go?

okiebon | @okiebon | Apr 26 3:50pm

In reply to @colleenyoung "@okiebon, I'm tagging a few members like @cyndielm @sallik74 @donna195 @wesleym @itlooksunny, who may have experience..." + (show)

@colleenyoung , first session was on Thursday. Went good, seems the dex causes the main side effects, lethargic and snacking. Took it Thursday and Friday so wearing out today.

sallik74 | @sallik74 | Apr 26 4:01pm

In reply to @colleenyoung "@okiebon, I'm tagging a few members like @cyndielm @sallik74 @donna195 @wesleym @itlooksunny, who may have experience..." + (show)

@colleenyoung
I am still smoldering multiple myeloma.
I know from others on my other support group, multiple myeloma warriors that everyone handles treatment differently.
Hopefully you will be one with little to no side effects

donna195 | @donna195 | Apr 26 4:42pm

In reply to @okiebon "@colleenyoung , first session was on Thursday. Went good, seems the dex causes the main side..." + (show)

@okiebon , i started treatment March 17 with just Darzalex and that afternoon I was diagnosed as active MM and they switched me to DVRd, weekly. My first cycle, i got a rash on my face and under my eyes from the Darzalex . I took 50 mg prednisone and within 24-36 hours it was gone. I am 7 weeks in this Tuesday and each week it was a little less inflamed. The Dexamethasone gives me 1-2 restless nights after treatment day, but once it wears off, I feel better.

I started Lenalidomide on March 24 and had a little rash on my face so they held it for 5 days and them i resumed my daily dose of 25 mg. After 14 days, I developed a red raised bumps rash all over my abdomen and under my breasts. It did not itch or burn. My Dr. Is holding it until my appointment with Autologous Stem Cell Transplant on May 1 to determine if we proceed with a plan for the rash or possibly reduce the dose.

I have 3 more cycles before the anticipated transplant . I will keep you posted. This is a journey not a race and the goal is to get into deep remission and stay there as long as possible. You got this! There is an army of mm warriors supporting you all the way!

itlooksunny | @itlooksunny | Apr 28 9:48pm

My husband had that combo with few side effects, mostly fatigue! Honestly staff are on top of it and give you a med when side effects happen! Don’t worry!

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