DUPIXENT (dupilumab)

Do you think it might have been Brensocatib he recommended for bronchiectasis? I think it's coming out soon (August target) and is used to decrease exacerbations.

Dupixent is used for inflammation including atopic dermatitis, some asthma and COPD cases and recently for chronic urticaria. I got it earlier this month, but haven't heard of it for bronchiectasis.

@pacathy I was and am familiar with what we hope is to come, the Brensocatib , so when he mentioned it I indicated to him that I was familiar with it and the possibility of patients taking it for BE. He mentioned it seconds after the Dupixent. I foolishly did not open up, nor did he, a full discussion of why Dupixent could be considered with BE.
My understanding is that both help with inflammation, is that your understanding?
I am going to ask all my specialist doctors about it and if they consider it with patients having dry eyes, Eczema and BE, and if so, under what conditions and circumstances with the patients problem and disease.
Barbara

@blm1007blm1007 I have been taking Dupixent for 7 months for asthma, BE, eczema, etc. (Also have Lupus and deep chronic lung infection).
Dupixent has helped, no side effects. The company calls to check on side effects often in the first few months.
I had chronic cough and out of control asthma for 8 months prior, with steroids and benzonatate as treatment until bronchoscopy showed infection. Antibiotics, anti inflammatory diet, and benzonatate are tamping down the infection and cough. Both lower lungs are affected, but I am doing well. If your doctor suggests it, I recommend following through with it.

I'm curious if you have a high eosinophil counts and which of your conditions was the indication for it. I just got a sample dose for urticaria.

I was just doing a quick review to respond to Barb and it seems high eosinophil counts are part of indication for its use. About 20% of bronchiectasis patients have high eosinophils-mine haven't been elevated.

@ pacathy
Thank you both for reading and responding.
I understand from a neighbor who has had Eczema since childhood that the Dupixent has done wonders for her.
Regarding the benzonatate I researched it and this is one thing it said regarding it. Were you told of this?
"It should not be used for chronic coughs associated with smoking, asthma, or emphysema, especially when there's excessive mucus production?" True it doesn't specifically say BE.
Did you have excessive mucus production before taking it.? Do you have excessive mucus production with taking it? I do have excessive mucus all day long. I also read somewhere on a BE Mayo thread.......don't know if it was you.....that the BE patient takes the benzonatate, mostly, if I understood correctly, a bit before going out when she is being social, restaurant outings etc.
It is interesting that no doctor has suggested to me to do the anti inflammatory diet, however, I have been doing my best to follow it. I also watch what I eat as a precautionary measure due to NJH belief that acid reflux plays a role with BE. So I also follow as best I can the acid reflux diet.
Regarding @pacathy mentioning eosinophils, mine are not elevated. However, my Neutrophils (showing infections and inflammation) are right on the border line of normal/high...about to go over to the high side.
Barbara

Barbara about a year ago my pulmonologist suggested cromolyn sodium nebulizer- an older kind of med, non steroid, as an anti inflammatory. I asked dr Griffith at NJH about using it and he said it’s rarely prescribed because there are better meds now, mostly with steroids. I have been using it. So may be ask your doctor

Thanks for reading and responding. "Mostly with steroids"......something to avoid if at all possible.
If you have more time to discuss:
Were you using the hypertonic saline solution to start with and then switched over to the Cromolyn sodium?
What was your journey with either one or the other?
How long on them or the one...... and what do you feel one was not doing vs the other....what has it done for you????? Recognizable change????
Barbara

Cromolyn sodium and sodium chloride are different nebulizers. I am using both, sodium chloride to moisturize the lungs and create unfriendly environment for the bacteria. Cromolyn is anti inflammatory. I would ask your doctor what his/ her thoughts are on this matter

@pacathy
I don't have high eosinophils either. I have intrinsic asthma and can not tolerate odors. My pulmonologist felt that it was a good idea since my nebulizer asthma meds and steroids were not helping me. The oscillating vest and postural drainage helped, too.