Cretastimogene Grenadenorepvec: Anyone in the PIVOT-006 Study?

Posted by nihifam4 @nihifam4, Mar 29 10:00am

Husband has had 5 Transurethral Resections of Bladder Tumor (TUBT) since 1999. Tumors low-grade cancer until now. Last surgery 5 tumors, high-grade cancer. The doctor wants him to do this Randomized Study of Adjuvant Cretostimogene Grenadenorepvec versus observation for the treatment of intermediate risk non-muscle bladder Cancer. Is anyone in this study?

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fmfran | @fmfran | May 27 6:59pm

Thanks. I’m still waiting on my results from my BCG. Can I enroll now or do I have to show that the BCG did not work..
Fran

djr5 | @djr5 | May 31 11:51am

In reply to @sparkyconnect "Just enrolled in trial last week at Mayo Jax Initial treatment to start in approx 3..." + (show)

I wish you the best, and hope you are included in the initial teratment arm of the study. Please consider posting about your ongoing experiences with the trial and, I sincerely wish, the successful results.

fmfran | @fmfran | May 31 6:52pm

In reply to @sparkyconnect "I just enrolled in the trial at Mayo Jax. Scheduled for randomization in approx 3 weeks...." + (show)

What is the protocol? Is it put in the bladder like the other treatments? How many and how often?
Thank you
Fran

vejan738 | @vejan738 | Jun 2 12:19pm

In reply to @djr5 "Hello, I was diagnosed low grade NIMBC in December 2023, had TURBT, Mitomycin and a course..." + (show)

headed for treatment with Adstiladrin within 2 weeks, 2 TURBT's tested lesions and came back positive. The cost for this new drug is out of this world but trials have really been promising

djr5 | @djr5 | Jun 2 3:07pm

In reply to @vejan738 "headed for treatment with Adstiladrin within 2 weeks, 2 TURBT's tested lesions and came back positive...." + (show)

I hope all goes well for you. You may want to bring a book or music/earphones to the treatment. Once it is administered, you have to stay on the table for an hour. Godspeed!

sparkyconnect | @sparkyconnect | Jun 3 4:45am

In reply to @fmfran "What is the protocol? Is it put in the bladder like the other treatments? How many..." + (show)

Trial info is available at CG Oncology website.
Very informative

nonnojoe | @nonnojoe | Aug 24 9:23am

I have been in this trial since January, 2025. Have received 6 initial weekly intervesical treatments, then month 3 a cystoscopy, then 3 weekly treatments, then month 6 cystoscopy, followed by 3 treatments. Scheduled for 9 month cystoscopy. If clear, then 1 treatment. Month 12 scheduled cystoscopy, followed by final treatment.
Main side effect is burning urination for a day after treatment, though last treatment had blood in urine and some passing clots for few hours after.
Treatment at Houston Methodist.