What treatment is effective for chronic headaches?

@jrsjc - welcome to Mayo Clinic Connect. The discussion you started is now part of the larger support group called Headache & Migraine, https://connect.mayoclinic.org/group/headache-migraine/. You might check out this link to see all the discussions in this group, some of which may relate to your situation.

Wondering if when you saw a doctor at your local headache center in Israel, if this is what they diagnosed you with? The treatments seem to potentially fall in line with the ones you mentioned you were prescribed.

- Chronic daily headaches https://www.mayoclinic.org/diseases-conditions/chronic-daily-headaches/diagnosis-treatment/drc-20370897

Do you have symptoms in addition to head pain? If so, will you share more about those?

Vyepti Infusion seems to be the only thing that has made any differences for me. Pain level 8 down to 4 (within 45 minutes) and slowly creeped up to a 6. Have to wait 3 months between infusion. After 3 infusions at 100mg, Neurologist said it can be upped to 300mg / infusion (insurance thing).

Things tried
- MRI with Imaging of Head and Neck.
- Topiramate 50mg to 100mg 2x/ day (brain fog so Neurology stopped - I kind of liked it)
- Propranolol 30mg 3x/day (I passed out due to low blood pressure so Neurology stopped. I had low blood pressure before starting)
- Emgality 120MG INJ (monthly - no effect on me)
- Ajovy 225MG INJ (monthly - no effect on me)
- Ketorolac Trometha 10MG (pain level 8 to 5 while taking)
- Migraine Infusion (#1) - lasted 3 days - Very Strong - Benadryl; Ketorolac (Toradol); Magnesium Sulfate; NaCI 0.9%; Prochlorperazine (Compazine); Methylprednisolone 4MG
- traMADol Hydrochlo 50MG Tab (pain level 8 to 5 while taking)
- Migraine Infusion IV (#2) - little effect - Very Strong - Acetaminophen (Ofirmev); dihydroergotamine (D.H.E. 45); Benadryl; Ketorolac (Toradol); methylPREDNISolone Sodium Succinate (Solu-Medrol); Metoclopramide (Reglan); NaCI 0.9%
- Eletriptan Hydrobr 40MG - Helps - I take it when migraine wakes me up at 2am to get back to sleep. Can only take every 4 days. Neurologist started on two other "Triptans".

For sinus infection, was on antibiotics and they seem to lower 24x7 headache / migraine pain level.
- Amoxi-Clav 875-125MG 14 Days
- predniSONE 10MG 12 Days

After going through this for the past year, Neurologist gave referral to Immunologist. That will be next year.

Everyone is unique.

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