Connect
Cat T ...after personality changes
I'm a caregiver for my husband who received a Car T cell therapy on March 23rd. He was in hospital for 12 days, came home for 10 days and returned for 8 more days for CRS and icans..he came home for another 16 days and returned with ICANS again for another week.
He has been home for 12 days. His personality is so different. He's angry, agitated, resentful, offensive and mean. A total shift in personality. Dementia like symptoms.
Has anyone else experienced anything like this???
Has anyone else
Like
Helpful
HugInterested in more discussions like this? Go to the Bone Marrow Transplant (BMT) & CAR-T Cell Therapy Support Group.
Connect
Hi @nfoltz I’m so sorry your husband is experiencing such a personality shift after his CAR-T therapy. This has to be so frightening and difficult for both of you.
It sounds like your husband has had a couple of recurrences for ICANS (Immune Effector Cell-Associated Neurotoxicity Syndrome), which is a neurological condition primarily associated with CAR T-cell therapy. It’s not uncommon and from my understanding it ICANS can often spontaneously subside. But it certainly can be a complication.
When your husband returned to the hosptial, what was the treatment he received to help with the symptoms?