Can Neuropathy be cured?

@michhino
As of January 2026 it will be 10 years since I was diagnosed with idiopathic SFN. I spent one week at the Mayo Clinic in Rochester back in June of 2021 hoping they might find a cause, they didn’t. I retired from a major pharmaceutical company and know how to research and interpret clinical trial data. I have had 2 trials of a Spinal Cord Stimulators which failed. I have taken every drug out there and every test multiple times. The only neuropathy drugs I take are pregabalin, duloxetine and Low Dose Naltrexone 4.5mg. The drug I had high hopes for was an injection called Engensis from a South Korean company called Helixmith. I have tried for several years to get an update on the drug but the company went dark. YESTERDAY, I finally received a reply from someone that used to work for the company here in the United States, and he told me they had 2 Phase III trials that did not meet the primary endpoint. They also a a money issue in continuing the research. Basically the drug is very much DEAD.
There is nothing out there that will “cure” idiopathic SFN. IF they can identify a cause, then hopefully treating the cause will cure the neuropathy. I have never heard. Of someone actually curing neuropathy. The only drugs in trial now that I know of address the pain only (palliative) and none come anywhere close to a cure. For pain, the first non-opioid pain killer invented is a drug call Journavx. It has a very unique mode of action, and can be effective in pain relief for some patients. Other drugs with a similar MOA are in research as well.
My industry has done an amazingly poor job in their approach to neuropathy. They will develop tons of me-too drugs but have failed miserably at dealing with the degeneration of nerves and reversing it.
I am not offering any medical advice, but be careful what snake oil salesmen are selling. Desperate people sometimes lose their ability to reason logically when looking for help. I will advise anyone with neuropathy to exercise AS MUCH AS POSSIBLE with aerobic and resistance training if you can. I truly believe it has he with my discomfort. Good luck to all of us.

@magnum52 thank you I hope you’re doing good and you keep up with everything I like to follow up with you on this. Since I have the same problem and taking the same medication as well. Please stay in touch. Merry Christmas

Hello @nattleu, I see you have been a member for awhile and this is your first post so I would like to welcome you to Connect. I'm glad to see that you have connected with @magnum52 who has shared some really good advice. In case you haven't already seen it, you might also find the Foundation for Peripheral Neuropathy helpful for suggestions on living well with neuropathy - https://www.foundationforpn.org/living-well/.

Do you mind sharing your diagnosis and what has helped you manage the symptoms?

@magnum52 thank you I hope you’re doing good and you keep up with everything I like to follow up with you on this. Since I have the same problem and taking the same medication as well. Please stay in touch. Merry Christmas

@nattleu
Reach out anytime. I am taking pregabalin 50mg twice a day; Low Dose Naltrexone 4.5mg daily which has to be compounded by a compounding pharmacy; and duloxetine 60mg daily. I also workout at the gym 5 times a week with weights and cardio. I believe this has helped me more than anything. We have to find what works for us be we cannot depend on the pharmaceutical industry for help or the various research institutions out there because they are only interested in symptom control and not finding a treatment that reverses nerve degeneration.

@magnum52 I will check out Natrexone and thank you