Can I stop meds for a day?

Hi, all. I'm having a difficult time getting an answer to this simple question from my doctor's office. Next month, I will have been on the Big 3 for almost a year, My fatigue typically grows during the week so that by Saturday, all I want to do is nap. This Saturday I will be attending a wedding out of town. I would like nothing more than to skip my meds on Friday to avoid the brain fog the next day. Does anyone see a problem with my skipping one day of meds?