Can I have an autoimmune disease with perfect lab results?

Yes

Were you ever tested for Lyme disease?

There is a special lab in CA that specifically targets lupus labs. I came across this post but I'm upstairs in bed now. My regular labs show .1 higher than the high on ONE lupus test! Lab said "no way lupus". Sent to specialty lab and came back Tier 1 SLE strongly positive. I don't trust the local labs nor the radiologists where I live. They're a nightmare. Keep searching. If that pic was you you certainly have the lupus butterfly rash.
Good luck!

@jodiemc. How did your appointment go? Did you learn anything or get a treatment plan?

Every test has the possibility of false negatives and false positives. Your physicians cannot treat you until they have a diagnosis. Until they know what’s going on, based on your symptoms and test results, any treatment or medications would potentially do more harm than good, since the treatment would likely be focused on an illness you don’t have, and leave untreated the illness you actually have. Also, please remember that health insurance will not pay for treatment or medication unless there’s an official diagnosis. It sounds like your physicians are as mystified as you are. My recommendation to you is to focus on things you can control. Drink lots of water, avoid “white” foods like sugar, bleached flour, pasta, and rice. Increase your consumption of fresh and/or frozen foods. Eliminate meat from your diet. Increase your exercise to 30+ minutes daily, swim or join a yoga class at your local YMCA. Volunteer at your local animal shelter 1+ days per week. Remain grateful you haven’t started treatment for a disease you don’t have and remain confident an answer will eventually be found

My daughter has had these sudden red heat rashes come and go for several years. We have never known what triggered them… EPI pens have had to be used in the past 4 months, as they have been progressing and increasing in frequency. Neurologist felt it was MAST cell activation as well, and referred us to Genetics testing and allergy.
Her labs are always “good” ANA’s wax and wane…. I understand your frustration.

Hola.
Parece que me escuchara a mi hace años.
Revisa el Cortisol...yo lo tenía bajito ,casi nulo y aun así mis laboratorios salían perfectos. Hoy en día tengo la enfermedad de Addison y Hashimoto.

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@lisalisa Have you been able to take your daughter to a geneticist? And have you learned anything? Your daughter’s symptoms seem to be increasing and you’ve been using an EPI pen.
Frequent use of an EPI pen could signal a progression of a disease.
Has she been back to the doctor who prescribed the EPI pen?

Looks like a classic butterfly rash found in Lupus if ever I saw one. Did you show the rheumatologist that photo of you?

I don’t have Lupus but I remained seronegative for Sjögrens Syndrome for eight years after getting ill. Fortunately the specialist doctors that I had treated me for the many individual debilitating symptoms I had which made life much more bearable. Then after eight years in 2015, finally my ANA’s and other markers were positive.

So yes, it is possible to have an autoimmune condition and for your blood testing to be negative.

The geneticist appt is still about 8 weeks away. We did recently see the Neurologist that prescribed the Epi pen recently and a new antihistamine and steroid medication was added. She has been 10 days without a rash. This is a marked improvement.