Can Gabapentin make neuropathy pain worse?

Posted by cwallen9 @cwallen9, Apr 16, 2019

I started getting peripheral neuropathy pain about nine months ago in my feet and hands right after I received a cervical steroid injection. I started taking gabapentin about 7 months ago. I have gradually increased my dose from 100 mg a day to 1500 mg. I can't say that it has decreased my pain at all. In fact, my pain has gotten steadily worse. I was just wondering if it is possible that gabapentin can sometimes make neuropathy pain worse. My EMG and biopsy results are negative for short fiber neuropathy so far.

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Profile picture for lwisely @lwisely

I have tried gabapentin twice. The first night I took it, I spent the entire night in the fetal position on the living room floor experiencing the worst pain I've ever felt in my life. I called my dr when the office opened and told them I could not take it. Several years later, another dr wanted to prescribe it and I told him what had happened. He said it was because I had been started on too low of a dose and asked me to please try it again at a higher starting dose. I hesitantly agreed and took it again. The EXACT same thing happened.

Another time I was given a pain relieving patch that I did not realize included gabapentin as an ingredient. Again...unbelievable pain.

I now include gabapentin on my list of drug allergies. I won't mistakenly take it ever again. When doctors ask what happens when I take it, I tell them about the pain and they never believe me.

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Perioperative Gabapentin Linked to Harms for Older Adults
Anita Slomski
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JAMA
Published Online: November 1, 2022
For older adults, the use of gabapentin to manage pain after major surgery can lead to adverse events in the hospital.

Perioperative gabapentin has increasingly been added to analgesia regimens to reduce opioid use among surgical patients. But studies in JAMA Internal Medicine casts doubt on the drug’s benefit for people aged 65 years or older.

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Profile picture for Jake @jakedduck1

@kinggypo
did you contact your physician and/or pharmacist regarding what happened?
If so, what did they have to say?
Take care,
Jake

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J: Yes, I told my internist who prescribed it and the head pharmacist at the hospital that fills my scripts. I'm very close to the pharmacist and was told that Gabapentin is off-label use for me. I have no idea why I was prescribed it other then a lame reason for neuropathy. I usually get scripts, because I inquire about it and do my due diligence/homework. Surprisingly, there's very little positive feedback on it. It's highly unusual for me to have adverse reactions to prescribed drugs. This happened within 1 hour and that never happened in my long life over a RX. I once was given adenosine for a chemical stress test and it caused a heart attack that almost killed me. I didn't need a chemical stress test and was capable of doing a standard physical stress test at that time. I tried to find if the cardiologist ordered the chemical stress test or the physicians assistant/nurse practitioner took it upon himself. The doctor played dumb and I refuse to see him because he's a hack. I went to college with a great guy, who went on to become a cardiologist. He's in Houston at Baylor but I'm not flying in to see him. In the 70s I worked at NASA (JSC) and it was great seeing him and other ultimate professionals. My 'kid' brother is a pediatric craniofacial plastic surgeon at the medical center there and teaches. He hasn't charged a fee in decades, so he donates his time and gets hospitals to pitch-in too. No ACA or Medicaid expansion in TX. I seriously considered seeing an attorney over that stress test. I heard many horror stories from many other men immediately after adenosine, or regadenoson, was administered. I didn't feel like Gabapentin might kill me, I was just blown away how it immediately adversely affected me. I'm not going to be an avenger over it like that over chemical stress tests with adenosine, or regadenoson! I was immediately rushed into ER and a "code blue" declared. I wouldn't take Gabapentin on a bet. It's been around a long time and now being pushed on patients. I've seen that on numerous meds over the years. I've told doctors certain drugs are going to get black box labeled from the FDA. My Internist said about my research is because being retired I have time to read and he's a working stiff. Which to me was BS because I did it in the Army flying choppers. I had my life and others to consider! Gabapentin was like me taking strychnine, a Victorian era medicine widely used. Maybe I need leeches or bloodletting? Just too much time on my hands before I die!

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Profile picture for Idied2x @1died2x

I am a 77 year old agent orange Vietnam PD recipient. I was also given Gabapentin. First day one tablet, second day two tablets, third day start am-noon-pm. I was on three tablets three days and threw the bottle away. My memory dropped from can't remember yesterday to can't remember 20 minutes ago. Every pain I had got worse. I truly just wanted to die and get it over with. All of my random pains became less random and more pain. I try to do 1 or two hours a night of research and I try to stay on the edge of as few drugs as possible and every morning my wife makes me a tonic of Tumeric, ASV, ginger, honey plus some Asian herbs - there are a lot of names and formulas but those are the basics. Mixed as a tonic of 8 ozs of room temp water. I chug it. I take all the more highly recommended vitamins like b, c, d, e . the dopa/dopa seems to help some but the natural stuff seems to be the most stable. After covid (I got it) I am looking at drug companies as enemies and if something doesn't help I stop it fast. I am not a doctor and I can be drummed off this site but I am the only one that really cares about me and if I don't like what its doing to me I stop it.

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@ybones787878
So sad to hear they did that to you, I experienced the same thing. Just tried to get a referral to a neurologist and instead they tried me on gabapentin and 3 days out , Bam! I was so cripple it was and been excruciating, fine when laying down but getting up is a nightmare. Can’t barely get up or out of bed without excruciating pain and can’t walk barely due to the pain .. The medical field has been taken over by Satan himself

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Was trying to to get a diagnosis for symptoms I have had similar to RMS was given Gabapentin and after 3 days of taking it I woke to a nightmare, I immediately stopped the pills due to that fact I couldn’t get out of bed, Was thrown into a extreme nerve flare comparable to polymyalgia rheumatica for about two months and now chronic pain and stiffness with muscle atrophy . I’m over 60 and should never have been prescribed such a unpredictable medication.

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Profile picture for Lisa Lucier, Moderator @lisalucier

A few members who may have some thoughts on whether gabapentin can make neuropathy worse whom I'd like to invite into this conversation are @jakedduck1 @lauraj155 @jackkdh @jmjlove @ahendershot.

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@lisalucier Gabapentin made my life HELL!

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Profile picture for stormyone @stormyone

@ybones787878
So sad to hear they did that to you, I experienced the same thing. Just tried to get a referral to a neurologist and instead they tried me on gabapentin and 3 days out , Bam! I was so cripple it was and been excruciating, fine when laying down but getting up is a nightmare. Can’t barely get up or out of bed without excruciating pain and can’t walk barely due to the pain .. The medical field has been taken over by Satan himself

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@stormyone Absolutely, I’m so angry, it is an abomination

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Profile picture for anigma @anigma

@lisalucier Gabapentin made my life HELL!

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I take 2400 mg. of Gabapentine daily.
What exactly did you experience ( same pain level, longer duration of pain, no improvement in the situation)?
I'm very concerned with my dosage.
Don't know if my pain level will be reduced and also long term effects.

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Cwallen 9
White matter in our brain is an insulating fat called myelin. Diet low in B12 causes myelin to leave the nerves being protected. Also older stomachs have less acid which extracts B12 from animal proteins. Alcohol further reduces absorbtion. Suggest u get B12 measured and go on supplement METHYLCOBALAMIN.

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