Can Gabapentin make neuropathy pain worse?

Posted by cwallen9 @cwallen9, Apr 16, 2019

I started getting peripheral neuropathy pain about nine months ago in my feet and hands right after I received a cervical steroid injection. I started taking gabapentin about 7 months ago. I have gradually increased my dose from 100 mg a day to 1500 mg. I can't say that it has decreased my pain at all. In fact, my pain has gotten steadily worse. I was just wondering if it is possible that gabapentin can sometimes make neuropathy pain worse. My EMG and biopsy results are negative for short fiber neuropathy so far.

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Could not tolerate that medicine made me sleepy and when I was awake did not know if I was in pain not also had severe side effects to Lyrica and it did not help the neuropathy at all

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What were side effects of Lrica per chance. I've switched to pregablin (lyrica) from Gabapentin which like you was a super sleepy pill slept years away before switching to Lyrica but now have developed bouts of severe leg weakness not sure if related to lyrica

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I have tried gabapentin twice. The first night I took it, I spent the entire night in the fetal position on the living room floor experiencing the worst pain I've ever felt in my life. I called my dr when the office opened and told them I could not take it. Several years later, another dr wanted to prescribe it and I told him what had happened. He said it was because I had been started on too low of a dose and asked me to please try it again at a higher starting dose. I hesitantly agreed and took it again. The EXACT same thing happened.

Another time I was given a pain relieving patch that I did not realize included gabapentin as an ingredient. Again...unbelievable pain.

I now include gabapentin on my list of drug allergies. I won't mistakenly take it ever again. When doctors ask what happens when I take it, I tell them about the pain and they never believe me.

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My experiemce with Gabapentin is different than many on this Blog. I fought for a few years using drugs until it was not worth it. I have been on gaba 300 mg 3x and it makes a hige differemce in my idiopathic PN symptoms. So far after a few years no issues other than positive relief from nasty Idiopathic PN.

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Hopefully you have a substitute to take. I took Gabapentin without any symptoms but everyone is different. Good luck.

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Profile picture for salsa @salsa

Obviously every case is different, but in mine I take 2700 mg a day. Alot I know, but before it my episodes would last an hour or so, it was brutal. Now, I still get my episodes but they last maybe 10 minutes to 15 minutes max. I don't like being on it, but my neurologist at the Mayo assures me it is ok. I always looking for other options, but no luck so far. Maybe an increase would help, as for me I would say taking it has not increased my pain, but has been a help in reducing episode length. Good luck to you, I hope you find some answers.

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Have you tried Pregabalin ( Lyrica?). It's been great for me. Just a thought.

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Profile picture for lwisely @lwisely

I have tried gabapentin twice. The first night I took it, I spent the entire night in the fetal position on the living room floor experiencing the worst pain I've ever felt in my life. I called my dr when the office opened and told them I could not take it. Several years later, another dr wanted to prescribe it and I told him what had happened. He said it was because I had been started on too low of a dose and asked me to please try it again at a higher starting dose. I hesitantly agreed and took it again. The EXACT same thing happened.

Another time I was given a pain relieving patch that I did not realize included gabapentin as an ingredient. Again...unbelievable pain.

I now include gabapentin on my list of drug allergies. I won't mistakenly take it ever again. When doctors ask what happens when I take it, I tell them about the pain and they never believe me.

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Dear @lwisely
That med I have the 1500, 3 times a day. Not pain, but anti-sezure (sp?).
Thx
Greg D. @greg1956

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I was prescribed it for diabetic neuropathy and I have mild Parkinson's. I take plenty of meds for other problems. The VA takes good care of me and my other doc's elsewhere. I use Insulin, (long and short acting), Jardiance, and Metformin. My A1C is at 6 and well managed. I use pain meds and don't feel guilty, that's what they're for. I'm not a junkie but a pretty old veteran who was in a bad chopper crash 55+ years ago. I never took my 100% disability for personal reasons. So, I'm not a complainer. Early on it was tough adjusting my GI to Metformin but otherwise I've never had crazy side effects from any other drugs in my long life other then Gabapentin! Gabapentin was like arsenic to me. Right after taking it my lower jaw started uncontrollably opening and closing. I'm telling you it was very fast and rough and quite painful. Trust me, I know pain and strange events but I can't say if was an adverse reactions versus a side effect! I don't scare easy either. I've walked next to water moccasins outside where I live and made them way for me. I will never take Gabapentin again! I take over 12 drugs and my give my care teams credit for keeping me alive. But, I'm 100% sure the Gabapentin had that adverse reaction on me. A one off event happening within 30 minutes of taking it in a long life. That's not a fluke event but a warning! I guess I'm older then many posters here but that crazy anomaly could've been my heart. It's a muscle that contracts. I'm not a test patient and Gabapentin is out! There are plenty of bad reviews on it and my neuropathy I can deal with and pain meds for pain. I hardly sleep but that's life. I take pills at 11pm for that and still see 1 and 2am go by. But Gabapentin is DOA.

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Profile picture for gregd1956 @gregd1956

I sorry for your pain from that meds. GABAPENTIN was started in the 1990’s and was made for pain. What type of pain? Legs, feet, or different body, but for me, I use that med, 3-times-a-day to anti-seizure on my TBI - a bicycle accident 12 yrs ago.

Cweelen9, you started to 100 mg then up to 1500 mg and lose the ability of that med for pain It never, ever was not my pain. Two years ago, from falling down in my garage, hit my 2 rear-ends and sent deep-pain under my rear-ends & my back of each bottom legs. I started this med, that anyone could buy the 100s like Walmart, but I used the 400s of pain-helping. Another 3-6 mths didn’t help me of my bottom of my body; pain, deep pain is there. Yes, I lost my balance that’s still moves to me of falling on my tight knee-down.

Over 2 mths ago, my doctor gave me a choice of fixing, or not, pain from my rear-ends down:
1) No help anti-pain - Leave it by itself and, maybe, it will work
2) Maybe help anti-pain - He could send me a newer anti-pain med.
3) Could help anti-pain to end it - 1.5 mths ago, I closed a surgery right close from my right-side of my top rear-end to the bottom of my back. I spent the next 5-days at that hospital. The pain was gone - no anti-pain meds at that hospital. So losing pain - that’s gone - and trying to walk a different way - with no pain. How would I needed to change a diff way of walking? That was there, even after my surgery. That changed of working on my exercising, lifting my balance and legs… stretching the muscles is a bit percentage.

Today, me weakness of my balance is still here; any pain of anything - NO, thankfully; walking again - only on my 4-step (sorry, my memory of that word is not there). Today, I don’t hold 100% of my 4-step, but hold things in my kitchen.

Sorry, my surgery was fixed my back to move my largest nerve between several part of my bone that’s stretches one part to another for 5 parts my lower back. I had photos on paper, but I can’t find it. I think my wife has everything. s

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In December 1993, the US Food and Drug Administration (FDA) granted approval for gabapentin, under the brand name Neurontin, for adjunctive therapy of seizures. Subsequently, the FDA approved gabapentin in 2000 for treatment of seizures in children aged 3 years or older and in 2002 for treatment of postherpetic neuralgia.

JAMA, updated Cochrane review on the use of gabapentin for neuropathic pain. The authors concluded that gabapentin is associated with reduction in acute pain associated with postherpetic neuralgia and peripheral diabetic neuropathy (the later indication is not approved by the FDA), and that there is no evidence to support the use of gabapentin for other types of neuropathic pain and pain disorders.

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@kinggypo
did you contact your physician and/or pharmacist regarding what happened?
If so, what did they have to say?
Take care,
Jake

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