Connect
Brensocatib FDA approval?
I know the new medication Brensocatib that a lot of us are waiting to hear if it’s FDA approved. I believe that date could possibly be on 8/12/25. Is there anyone in this forum that will monitor a certain sight, webpage, program, etc that will be able to inform the other members of this group if in fact it did get approved? I know for one have two of my Pulmonologists ( one at UVM & one at Mayo Jax) say I’ll be an excellent patient to try it, because they believe my inflammation is caused a lot by high neutrophils in my blood work. So I’m extremely anticipating the approval/disapproval announcement. Any info on how we’ll find out will be helpful. Thank-you one & all.
Like
Helpful
HugInterested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.
Connect
I am in exactly the same boat and looking forward to then 12th with great anticipation. Everything I hear (nothing official) is that it stands a very good chance of approval. How long it actually takes to get it out to us all is another matter. I am headed to Mayo Jax on the 4th and should have a slightly better handle on all that after my visit. Will try to update everyone then. PCIII
-
Like -
Helpful -
Hug
2 ReactionsWhen you say they believe your inflammation is caused by high neutros, what exactly is the inflammation you experience? How high are your Neutros? I am curious because my Neutros are high but I attribute it more to infection than inflammation and wonder about the Brensocatib for my situation.
The lab my bloodwork is sent to considers the normal range 42.2 - 75.2. I think all labs differ slightly. I was always under the impression that the high neutrophils is a component of if not causing some of the inflammation in our lungs which for me causes alot more mucus for me to expel when my neutrophils are a lot higher than the normal range. Mine have been 90, and 88 at one time and I noticed much more mucus to expel and harder also. I usually run upper 70’s to low 80’s but a slight noticeable difference in easier to expel mucus. I remember hearing Dr. Charles Daly from NJH stating that 80% of patients with BE have high neutrophils in their bloodwork and he believes it is a driving force contributing to inflammation. I also believe he was basically the inventor or one of them who (along with the pharmaceutical company) developed Brensocatib. Anyone please feel free to correct me if I’m wrong. I cannot remember if I had infection during those 88 & 90 counts. But my latest neutrophil count from 4 days ago was 75.4. Below what I’ve been in the past, and I do notice a difference in the effort to do airway clearance.
I guess the whole thing about Neutrophils is still not clear to me. There are # of Neutrophils and % of Neutrophils. With your numbers I guess you are referring to %. But how do they know the elevated numbers are more from infection than inflammation.