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Brensocatib FDA approval?

MAC & Bronchiectasis | Last Active: Aug 20 2:19pm | Replies (21)

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When you say they believe your inflammation is caused by high neutros, what exactly is the inflammation you experience? How high are your Neutros? I am curious because my Neutros are high but I attribute it more to infection than inflammation and wonder about the Brensocatib for my situation.

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Replies to "When you say they believe your inflammation is caused by high neutros, what exactly is the..."

The lab my bloodwork is sent to considers the normal range 42.2 - 75.2. I think all labs differ slightly. I was always under the impression that the high neutrophils is a component of if not causing some of the inflammation in our lungs which for me causes alot more mucus for me to expel when my neutrophils are a lot higher than the normal range. Mine have been 90, and 88 at one time and I noticed much more mucus to expel and harder also. I usually run upper 70’s to low 80’s but a slight noticeable difference in easier to expel mucus. I remember hearing Dr. Charles Daly from NJH stating that 80% of patients with BE have high neutrophils in their bloodwork and he believes it is a driving force contributing to inflammation. I also believe he was basically the inventor or one of them who (along with the pharmaceutical company) developed Brensocatib. Anyone please feel free to correct me if I’m wrong. I cannot remember if I had infection during those 88 & 90 counts. But my latest neutrophil count from 4 days ago was 75.4. Below what I’ve been in the past, and I do notice a difference in the effort to do airway clearance.