@gently
Thank you for your informative response. I wish I would have known more before I had Reclast infusion. I also had cancer last year and was having Nivolumab immunotherapy infusion. After 4 months of that, I started noticing a reaction in my body (but milder than after Reclast.) I stopped the immunotherapy but 2 months later had the Reclast infusion. There is one Dr. that thought the Nivolumab caused a adrenal insufficiency or set-up the inflammatory process for the Reclast. I just don't know how to proceed with my new Rheumatologist, who I meet via telemed tomorrow. In the .gov link you sent, it mentions tests to rule out PMR. Also, my Primary said Reclast stays in system for one year. Can I find information stating 10 years? Thank you again.
@kabmax259,
Zoledronate in the bone isn't causing the reaction. Rather the reaction is self sustaining or has triggered other immune reaction no longer dependent upon the bisphosphonate. Less than 1% of the drug remains in serum within 24 hours. It is secured in the bone (This is why five day prednisone might stop the reaction. ) and is released in small amounts when osteoclasts try to attach to the bone.
I can't find the article, but spoke with the pathologist who authored it. He said, interestingly, but not relevantly to your post, that the bisphosphonate adheres in clumps not evenly at all, at the sites where bone is already weakened.
I hope that you have a good appointment with the rheumatologist who is sure to be more familiar with PMR and arterial inflammation than with Reclast effects. Maybe you'll post his views. I like the telemeds because you can record them.
I like the doctor who made the possible connection between immunotherapy and the susceptibility to this inflammatory reaction.
You've been through too much already.
dannyandebbie, that would be my impression. I'm only qualified to guess, but it's nice of you to affirm my suspicion. Do you have confidence in the AS diagnosis.
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@kabmax259,
Zoledronate in the bone isn't causing the reaction. Rather the reaction is self sustaining or has triggered other immune reaction no longer dependent upon the bisphosphonate. Less than 1% of the drug remains in serum within 24 hours. It is secured in the bone (This is why five day prednisone might stop the reaction. ) and is released in small amounts when osteoclasts try to attach to the bone.
I can't find the article, but spoke with the pathologist who authored it. He said, interestingly, but not relevantly to your post, that the bisphosphonate adheres in clumps not evenly at all, at the sites where bone is already weakened.
I hope that you have a good appointment with the rheumatologist who is sure to be more familiar with PMR and arterial inflammation than with Reclast effects. Maybe you'll post his views. I like the telemeds because you can record them.
I like the doctor who made the possible connection between immunotherapy and the susceptibility to this inflammatory reaction.
You've been through too much already.
dannyandebbie, that would be my impression. I'm only qualified to guess, but it's nice of you to affirm my suspicion. Do you have confidence in the AS diagnosis.