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Bispecific antibodies For Multiple Myeloma

Posted by lgeorge @lgeorge, May 26, 2023

Good Day,
Has anyone investigated or have been offered Bispecific antibodies to treat multiple myeloma or for any type of cancer? If so, have you heard or have you gotten good results with this treatment?

Interested in more discussions like this? Go to the Blood Cancers & Disorders Support Group.

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Colleen Young, Connect Director | @colleenyoung | Jun 5, 2023

@lgeorge, I had to look up this new treatment option for patients with myeloma that uses antibodies to activate the patient's own T-cells to kill their tumor cells.
- Bispecific Antibodies in Multiple Myeloma: Opportunities to Enhance Efficacy and Improve Safety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046900

Is this treatment option available for you? Will you be part of a clinical trial?

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lgeorge | @lgeorge | Jun 5, 2023

Well not at the moment. I have been following it but i wasn't sure if anyone as of yet been offered this as a first line of treatment.

Thank you for the article

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scottp777 | @scottp777 | Mar 26 11:56am

Yes. I was treated with what was going to be called Pavarutamab, which in the study was called AMG-701. Amgen pulled the study because two other drugs were FDA approved before Amgen could get theirs out. I received it for one year. I was able to achieve MRD Negative for one month, which was great. I'm now at "small monoclonal protein detected, " and have been for almost two years. Side effects were not bad.

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Colleen Young, Connect Director | @colleenyoung | Apr 6 12:42pm
In reply to @scottp777 "Yes. I was treated with what was going to be called Pavarutamab, which in the study..." + (show)
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Yes. I was treated with what was going to be called Pavarutamab, which in the study was called AMG-701. Amgen pulled the study because two other drugs were FDA approved before Amgen could get theirs out. I received it for one year. I was able to achieve MRD Negative for one month, which was great. I'm now at "small monoclonal protein detected, " and have been for almost two years. Side effects were not bad.

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@scottp777, it sounds like the trial drug helped you. Should treatment be necessary in the future are you eligible for one of the other approved drugs?

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scottp777 | @scottp777 | Apr 6 1:58pm
In reply to @colleenyoung "@scottp777, it sounds like the trial drug helped you. Should treatment be necessary in the future..." + (show)
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@scottp777, it sounds like the trial drug helped you. Should treatment be necessary in the future are you eligible for one of the other approved drugs?

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I am still eligible for Cart-T, and a host of other treatments. AMG701 was a bi-specific to BCMA/CD3, and since I responded well to it, there is an expectation that CART-T would work well also, should I need it in the future.

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Colleen Young, Connect Director | @colleenyoung | Apr 12 2:31pm
In reply to @scottp777 "I am still eligible for Cart-T, and a host of other treatments. AMG701 was a bi-specific..." + (show)
Profile picture for scottp777 @scottp777

I am still eligible for Cart-T, and a host of other treatments. AMG701 was a bi-specific to BCMA/CD3, and since I responded well to it, there is an expectation that CART-T would work well also, should I need it in the future.

Jump to this post

If the time comes for CAR-T Therapy, you might be interested in following the discussions in the group here:
- Bone Marrow Transplant (BMT) & CAR-T Cell Therapy Support Group https://connect.mayoclinic.org/group/car-t-cell-therapy/

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jrsav | @jrsav | Aug 31 10:07am

I have hair loss, exhaustion, mouth issues, skin peeling. All over skin peeling - kind of like body dandruff.
Anhidrosis - I stopped sweating. The associated issues to my Anhidrosis are very serious and life threatening.

For others it's not such an issue. Many don't even notice they have it and if they do have the Anhidrosis related issues - mostly heart stuff -
They don't know it's Anhidrosis related
Previously I sweated a lot. I'm normally very active and outside a lot. This year, I noticed rather quickly I wasn't sweating when I should have been and the Anhidrosis really kicked my butt.

I haven't had much luck finding out anything about treating anhidrosis.
I found it's related to neuropathy and Talvey hair loss. It's rare.
Ginger may help a little.
A long time anhidrosis sufferer uses MetaSweat for horses. I haven't looked into that yet - I just heard this yesterday

I get covered by little bumps at every sweat gland along with othe related inflammation

I've also heard of Talvey hurting T cells
Possibly. Affecting future treatment.
Is there a way to monitor if the Talvey is hurting your T cells?

Is there a good time to take a break from Talvey?

I realize, I would have to spend another week in the hospital to restart Talvey. Depending on how long I wss off of it.

I am MRD as of last week
I am scheduled for weekly injections through November - it's now August 31. 2025

There's also the quality of life issues

Might red light therapy help?

Anything else that might help?
https://www.google.com/search?q=MetaSweat&client=ms-android-verizon-us-rvc3&sourceid=chrome-mobile&ie=UTF-8

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