Benign fasciculation syndrome vs Amyotrophic Lateral Sclerosis
My grandfather had ALS (46 y.o. onset), my mom had some undefined dementia (45 y.o. onset, and I am inclined to think now it was FTD). I am 41 now. My concern is twitching soles (the side fine muscle where the arch is). Right sole is way more intense than left. It twitches every 3 seconds, non-stop, 24/7. Firing is not intense. And I have no idea for how long it has been there, month or years. I noticed 7 months ago when my soles started hurting after a long walk or run. I went to see neurologist, underwent EMG and NCV which was clean. No other symptoms such as weakness or muscle waste. So Dr. agreed it's BFS. I've read tons of studies, articles, talked to people firsthand. Everyone with BFS reports twitching of multiple muscles – that is widespread, and I have twitching of only one specific muscle – even if it's on both sides. Yes, sometimes I had that all-over-body twitching too, since I am an anxious person with a range of psychosomatic symptoms. But I am really concerned about my sole. Can BFS persist forever only in one muscle symmetrically? Can fasciculations precede weakness years before ALS onset? Can it be a coincidence that someone with ALS in the family surprisingly have BFS? Having read tons and tons of material, I have never come across some similar situation. It's such a grey area in science. At times I am so scared feeling like I am walking on the edge of 2 outcomes. And I am not ready to get tested for genes since not sure if I can deal with the results in case it's unfavorable.