Autoimmune disease induced by allergen specific immunotherapy.
I want to share my story with you and know if anyone else has gone through this situation.
I suffer from Relapsing Polychondritis (an immune-mediated inflammatory disease) with renal involvement in the form of mesangial nephropathy, (which has evolved leading to fibrosis and glomerulosclerosis and almost end stage kidney disease) , I developed the disease at the age of 13 in the distant 2002 during the application of allergen-specific immunotherapy (allergy shots)
Because allergen-specific immunotherapy causes changes in the immune system, it is possible that it may influence the induction of diseases mediated by the immune system, such as autoimmune diseases, even some doctors point to the induction of autoimmunity as one of the possible long-term consequences of allergen-specific immunotherapy.
Increased levels of IL-10, TNF, and TGF-B, as well as changes in Treg cells and the Th2/Th1 balance, are the mechanisms that can cause autoimmune problems in people undergoing allergen specific immunotherapy (Thats the goal of allergy shots, shift the immune system from th2 to th1)
Relapsing polychondritis is a Th1 and IL-10 mediated condition, while mesangial nephropathy is mediated by TGF-B.
In the medical literature there are many cases published over several years such as that of Dr. Ghorschi et al, “Manifestation of rheumatoid arthritis during specific subcutaneous immunotherapy of allergens”, “Scleroderma related to specific immunotherapy. Clinical Case Maciel BM, Morphine BM.” "Turkcapar N, M. Sjogren's syndrome induced by specific immunotherapy.", Pemphigoid-type reaction due to specific immunotherapy with allergen: an unusual adverse reaction Margarita Tomás-Pérez, "Autoimmune thyroiditis detected during allergen-specific immunotherapy: a case report Ahmet TÜRKELİ " among others.
The MDs, PhDs. Allan Linneberg and Andrzej Bozek carried out investigations where the cases of autoimmune disease that have appeared during or after the application of Specific Immunotherapy are indicated. Many of these cases have not been published, and as Dr. Linneberg mentions, it is a sensitive issue that requires significant action.
In the main guidelines for the use of specific immunotherapy, such as the EAACI , the DGAKI and the forums of the American Academy of Allergy, Asthma and Immunology AAAAI, this sensitive topic is mentioned.
My disease, other people's diseases , acknowledge the great ignorance and uncertainty of allergists that prevails in this area and call for a strong precautionary principle in relation to autoimmune diseases and allergen-specific immunotherapy.
I was negligently treated by an Allergist member of the National Council of Clinical Immunology and Allergy (CONICA) of México , my case was not published in the literature.
And that is why it is extremely important to evaluate people in terms of autoimmunity risk before starting SIT, my situation (along with that of other people) must not be repeated.
My body and my health were destroyed by Allergen Specific Immunotherapy and a negligent Allergist.
Has anyone else had any negative effects from allergy shots? or worsening of your autoimmune condition?
Thanks to all