Anyone take prednisone with tacolimus?

I took prednisone for the first six months after my heart transplant along with "Mike" and "Tac". It took quite some time to work out the right Tac dosage which is normal so I am not sure that had anything to do with prednisone. Mayo told me that prednisone has two potential side effects. First it can make you a bit of a jerk which was my primary worry as I have natural jerk tendencies. Luckily, I became subject to the second potential side effect; unaccustomed and overt emotional response. Commercials could make me cry.
Best always,
s!

Yes, I have taken that combination on/off the last three yrs. Prednisone affects each person in different ways it made me anxious moody tired I also had some GI issues. It never seem to affect my tac levels.
I hope u will do ok on your new med combination. It’s definitely a roller coaster ride.💚😊

I have been on prednisone and Tach since my transplant (May 2022). It does make me a little more "angry" as my husband and son put it. I just don't have the patience of talking loud because they can't hear me. So it sounds like I am angry when I need to talk louder to them. I have also been a little more emotional. I cry during shows when I think someone is going to die. However, I have always had a shortage of patience though and I have been emotional at times previously. It has just made both a bit more noticeable.

Since my kidney transplant in Jan 2023, I have been taking Envarsus (tacrolimus), Myfortic (Mycophenolate) and Prednisone 5 mgs. In 2000, I had rare an autoimmune disease and took prednisone for 5 years in varying doses. It caused me to have hair loss, cataracts and low bone density mostly in my hips so I now have osteopenia. Since my transplant, transplant, I am having hair loss, sinus issues, knee joint issues and had to have cortisone shots in each knee to stop the pain to be able to walk. I also had ulcers in the past and now suffer from gerd since my transplant and take Pepcid everyday. I am also emotional, have sleep issues and sometimes have mild hallucinations during the night. I have been sleeping in the guest room because I am awake on/off most of the night and disturb my husband. On a few occasions I have heard my husband walking in the living room and playing music . When I got up to check, he was sound asleep. I want off prednisone because it has affected me in the past and it is affecting me again. I was told by the transplant team that I have to take prednisone for the rest of my life. Appreciate any suggestions and/or similar expreiences and solutions. Many thanks.

Thanks for the responses everyone. It took a lot of Tac dosage to get to trough level. I just didn’t want the prednisone to cause any interaction with that. I will be on 5 mg twice a day. Nervous about the switch but my wbc count is low and positive for cmv is why I have to switch. Take care everyone.

I take Tac and prednisone. It definitely has side effects. My hair is falling out, and what is left looks like a Brillo pad. I turned completely gray after the surgery, and have excess facial hair. My moods are many, and I’ve lost my patience. Now that I am aware of these things, I have to deal with it. I am trying to be more patient. I am dealing with the hair loss by wearing short hair. Having the transplant was a great thing, but there are trade offs with lifestyle. I have suffered from BK virus for a year, hence the need for prednisone.

I’ve been on both but fairly recent liver transplant in 9/18/2023. Mine is adjusting just fine and I’m on the taper down of prednisone (prednisone is a strange one though because it affects everyone differently). I can tell you be very careful to eat when you’re taking these two meds together because it can affect the tachro levels. Mine is constantly being adjusted.

I’m 18 years post pancreas transplant. At that time the Tx Center had a protocol to avoid steroids. My immune suppression was Tacrolimus / Prograf and Mycophenolate / Cellcept. I had an antibiotic Bactrim Sulfa Trimeth. I had an antiviral Valcyte. Plus there was a troche of some kind to dissolve in my mouth. I had an issue with my white blood cell count that was attributed to Mycophenolate and I was switched to Sirolimus / Rapamune. I tested positive for CMV before the transplant and had an increase in CMV many years later. At that point the Valcyte was resumed for awhile. Prednisone wasn’t considered for immune suppression or to treat CMV. I have only had it once to treat pneumonia. It was beneficial for treating pneumonia but spiked my blood sugar into the 600’s. I am diabetic and REALLY hated that. I have a mistrust / dislike of prednisone ever since.

Like you I had a spike in my blood sugar after taking prednisone. I am only ten weeks post liver transplant, I’m still on 5mg daily and taking prograf and valcyte. My potassium level went high and now I take lokelma which helps a little. My biggest problem is hot flushes, did or do you experience any of this , I’m too old for menopausal symptoms so I know it’s not this. I’d like to know if these go away after medication I’d like to know if these subside after stopping prednisone.

I have hot flashes and have since 8-7-23. I only started prednisone 2 weeks ago so in my case it isn’t the reason for hotflashes but Tacrolimus is. Abou