1. < Chronic Kidney Disease (CKD)
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Anyone take a PPI & your kidney function declined?

Posted by sallylynn @sallylynn, Jun 3, 2024

Hi. I have a question. I will try to abridge this.
12/2/2023. Was prescribed Pantoprazole by PCP foe erosive esophagitis/GERD. I was EXTREMELY hesitant to take it since I did a deep dive of research on PPI's
I ended up NOT taking at first & just took OTC Pepcid A.C.
I was not getting relief so I started taking 1 Pantoprazole 20mg a day.
Ar times I would take 1 Pantoprazole A.M. 1 Famotidine 20mg P.M.
For months (5) I would go days, or a week not taking any medication. On and off basically.
Less than 10 times in several months, I took smallest amount of Gaviscon at bedtime.
My ENT doctor prescribed Sucralfate suspension
This medication is to coat stomache lining & esophagus fro "healing".
I stopped taking it after day 20. This drug has aluminum in it and Silica.
*COMPARISON OF BASIC METABOLIC PANELS:
12/26/2023- CREATININE 1.08/ eGFR 61.
05/22/2024- CREATININE 1.23/ eGFR 49.
* A doctor wrote a message on my 05/22/20224 BMP results stating my results ore OK, your creatinine is a bit higher, everything else is good.No mention on my eGFR. Told me to drink some more water to help my creatinine.
* On 05/07/2024 I wrote a My Chart message to my PCP that starting on 05/05/2024 my feet and hands are tingling & through the night. My feet are aching & tingling but my hands get tingle zaps.Let's call it neuropathy. It comes & goes. Not constant. Now, why I am concerned is the Kidney foundation on the Web does say kidney problems can cause hands and feet to "Tingle". I reached out to my Clinic, spoke to a nurse with my concerns, and the jest of it is, I might as well have been speaking to a painting on a wall. I feel justified to be worried hence the drop in my eGFR and rise in my creatinine but the doctors are not? I am terrified by me taking pantoprazole has permanently damaged my kidneys, and yes, it does. If a PPI causes CKD, it is permanent. AKI from PPI's IS reversible. Anyone out there with a similar situation? I see my "New" PCP on 06/10/2024 and another BMP lab on 06/17/2024. Any other lab suggestions? Thank you and God bless.

Interested in more discussions like this? Go to the Chronic Kidney Disease (CKD) Support Group.

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Mentor
Ginger, Volunteer Mentor | @gingerw | Jun 7, 2024
In reply to @sallylynn "Hello Ginger. May I ask please if you ever had the Cystatin C test? I have..." + (show)
Profile picture for sallylynn @sallylynn

Hello Ginger. May I ask please if you ever had the Cystatin C test? I have been reading about it. I'd be a liar if I said I wasn't scared. IF I didn't have this intermittent achy/ neuropathy in my feet and hands I probably wouldn't be as scared. I feel a lot anger and fear right now Ginger. I am angry because all for I know my eGFR has been hovering in the 40's for months and that is why I possibly have symptoms now! I was denied a blood test to check how my kidneys were functioning! Actually ENT sent a referral to her for a BMP and no response & then my gastrologist as well, which was ignored! I could have gotten off my meds after a couple months being on them! Yes, I am livid. Very livid! And yes, the Administration at my Clinic received a complaint from me. I want **** reprimanded. ~ My new PCP right off the bat was pro active, however, Administration is now involved in my situation so they may have had a say about the nephrologist and that is why I had a swift referral, but I pray my new PCP will be on top of the game. I am just...devastated. 🙁

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@sallylynn No, I never have had a Cystatin C test for eGFR. My insurance will not cover it. Being a kidney disease patient for over 20 years, my medical team and I found the standard test to be sufficient for my situation, without the added cost.
Ginger

REPLY
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jmedj55 | @jmedj55 | Sep 17 7:13pm
In reply to @sallylynn "Thank you very much for your kind comment, that means much. ~ It's been a rough..." + (show)
Profile picture for sallylynn @sallylynn

Thank you very much for your kind comment, that means much. ~ It's been a rough road in the arena with my medical care. I am very angry at myself for ever submitting to taking Pantoprazole with me knowing how dangerous PPI's are. This is from Google: Latest Proton Pump Inhibitor Lawsuit Updates As of June 2024, 18,668 people in the U.S. have filed lawsuits against PPI manufacturers after developing renal problems. Of these cases, 12,769 are still active as the settlement process is underway.
Look how many People developed renal problems taking PPi's!!!!! This is just the USA!
I kept getting reassured PPI's are safe with short term use. I took Pantoprazole on and off for approx. 3-4 months. I took Famotidine20mg pretty regularly which is a H2 blocker antagonist. What angers me beyond words is the gas lighting from my former PCP who is no longer my doctor.For months I begged her to please order a BMP for me.She kept refusing. IF she would have put in the order for me at least 2 months ago, like I begged her to do, I could have found out sooner my creatinine was elevated & my GFR was substantially lower and I would have immediately stopped all those meds! I spoke with a nurse this morning and asked her to please tell mt new Doctor to order a Cystatin C blood test, I guess these are more accurate than a BMP. ~ I stopped all my medications after I saw my results. No more PPI's , H2 blockers or sucralfate. I pray my next blood work there will be improvement.

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Sally , I have now experienced the same issue . I have Barrett esophagus but after taking Prilosec for almost 4 months my kidney function has plummeted . I am devastated

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mintercreekin | @mintercreekin | Sep 18 10:51am

I am on a PPI, Pantoprazole, and my kidney functions are declining. I've been on this for 4 weeks. Still having heartburn -
Is it just the Sulfalcrate that has the silica in it?

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Mentor
Ginger, Volunteer Mentor | @gingerw | Sep 18 11:50am
In reply to @mintercreekin "I am on a PPI, Pantoprazole, and my kidney functions are declining. I've been on this..." + (show)
Profile picture for mintercreekin @mintercreekin

I am on a PPI, Pantoprazole, and my kidney functions are declining. I've been on this for 4 weeks. Still having heartburn -
Is it just the Sulfalcrate that has the silica in it?

Jump to this post

@mintercreekin Welcome to Mayo Clinic Connect!

Do you have existing kidney issues? When you mention your kidney function is declining, what are the tests showing for values of the eGFR? We like to look at trends rather than a one-time value, unless you are experiencing an acute medication reaction. Other things that can affect your reading is an infection, or poor hydration.

I would suggest you interface with your prescribing doctor and let them know about the declining function. That medication may not be the best one for you if there are still symptoms it is supposed to alleviate. Will you let me know what your doctor says?
Ginger

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mintercreekin | @mintercreekin | Sep 19 1:19pm

Yes, I have FSGS and my egfr is 22, as of Sept. 16th. In August it was 24. I am currently taking prednisone to hopefully have a positive impact on my kidney health, but so far to no avail.

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