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Anyone take a PPI & your kidney function declined?
Hi. I have a question. I will try to abridge this.
12/2/2023. Was prescribed Pantoprazole by PCP foe erosive esophagitis/GERD. I was EXTREMELY hesitant to take it since I did a deep dive of research on PPI's
I ended up NOT taking at first & just took OTC Pepcid A.C.
I was not getting relief so I started taking 1 Pantoprazole 20mg a day.
Ar times I would take 1 Pantoprazole A.M. 1 Famotidine 20mg P.M.
For months (5) I would go days, or a week not taking any medication. On and off basically.
Less than 10 times in several months, I took smallest amount of Gaviscon at bedtime.
My ENT doctor prescribed Sucralfate suspension
This medication is to coat stomache lining & esophagus fro "healing".
I stopped taking it after day 20. This drug has aluminum in it and Silica.
*COMPARISON OF BASIC METABOLIC PANELS:
12/26/2023- CREATININE 1.08/ eGFR 61.
05/22/2024- CREATININE 1.23/ eGFR 49.
* A doctor wrote a message on my 05/22/20224 BMP results stating my results ore OK, your creatinine is a bit higher, everything else is good.No mention on my eGFR. Told me to drink some more water to help my creatinine.
* On 05/07/2024 I wrote a My Chart message to my PCP that starting on 05/05/2024 my feet and hands are tingling & through the night. My feet are aching & tingling but my hands get tingle zaps.Let's call it neuropathy. It comes & goes. Not constant. Now, why I am concerned is the Kidney foundation on the Web does say kidney problems can cause hands and feet to "Tingle". I reached out to my Clinic, spoke to a nurse with my concerns, and the jest of it is, I might as well have been speaking to a painting on a wall. I feel justified to be worried hence the drop in my eGFR and rise in my creatinine but the doctors are not? I am terrified by me taking pantoprazole has permanently damaged my kidneys, and yes, it does. If a PPI causes CKD, it is permanent. AKI from PPI's IS reversible. Anyone out there with a similar situation? I see my "New" PCP on 06/10/2024 and another BMP lab on 06/17/2024. Any other lab suggestions? Thank you and God bless.
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@sallylynn No, I never have had a Cystatin C test for eGFR. My insurance will not cover it. Being a kidney disease patient for over 20 years, my medical team and I found the standard test to be sufficient for my situation, without the added cost.
Ginger
Sally , I have now experienced the same issue . I have Barrett esophagus but after taking Prilosec for almost 4 months my kidney function has plummeted . I am devastated
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Hug
1 ReactionI am on a PPI, Pantoprazole, and my kidney functions are declining. I've been on this for 4 weeks. Still having heartburn -
Is it just the Sulfalcrate that has the silica in it?
@mintercreekin Welcome to Mayo Clinic Connect!
Do you have existing kidney issues? When you mention your kidney function is declining, what are the tests showing for values of the eGFR? We like to look at trends rather than a one-time value, unless you are experiencing an acute medication reaction. Other things that can affect your reading is an infection, or poor hydration.
I would suggest you interface with your prescribing doctor and let them know about the declining function. That medication may not be the best one for you if there are still symptoms it is supposed to alleviate. Will you let me know what your doctor says?
Ginger
Yes, I have FSGS and my egfr is 22, as of Sept. 16th. In August it was 24. I am currently taking prednisone to hopefully have a positive impact on my kidney health, but so far to no avail.
I have had a chronic kidney disease for 8 years now and it's a very rare one that I got secondary to some autoimmune disorders that I have.
I was down at Mayo Clinic a year ago for two different visits and basically for a third opinion and they advanced me to a stage 3B down there. Other than that they confirmed that both opinions I had locally here or accurate it's the disease I have is very difficult to control and keep under control and once it gets out of control it's hard to get back under control.
Now my creatinine and GFR I'd have to look at my chart for my GFR but I usually go by my creatinine and I've had I have lab work every month 8 years ago I was in the hospital every 2 months in kidney failure with a creatinine of anywhere from 1.5 to 4.0 and 4.0 near dialysis. I did not need to be put on dialysis I still don't because I'm doing very well now.
I did a lot of changes in my diet because I also met with a dietitian at Mayo so I cut all pop out of my diet I don't drink any pop anymore I don't drink anything with sugar in it and I have to really watch my sodium content because even things like Gatorade are hard on your kidneys because of their sugar and the sodium content.
One eyeful was first diagnosed creatinine was baseline normal around a 1.4 and as long as it stayed around that everything was you know functioning properly still and right now the last 3 years my creatinine for the most part unless I have a stone causing a blockage my creatinine is back at normal levels and it's simply by cutting out pop drinking 3 l of water a day and cutting down on the sodium and doing lower protein and extra citrus for me but from what Mayo Clinic told me is citrus is very good for the kidneys so I also drink a quarter cup of lemon juice everyday if you like to mix it with water you can but I don't like lemon flavored water so I just take a half a shot in the morning and a half a shot of that quarter of a cup in the evening and I eat as many oranges and as I can and citrus.
I have been on protonix 20 mg twice a day for as long as I can remember 20 years at least since it came out and they've never said anything Mayo Clinic didn't when I was there either about that causing any problems with my kidneys based on your kidney function you're creatinine that is pretty close to normal but if you're worried you can always self-refere yourself to Mayo Clinic and go in well they'll find out when they call you if they feel like it's something that you need to do to look into it. I'm no doctor I can just tell you based on my lab results my Norm used to be baseline for me my normal used to be like a 1.4 anything over that I usually had a blockage and now it's back to normal so that's all I can tell you is your creatinine levels seem to be normal and even if they're elevated a little bit that doesn't necessarily signify it like a cute kidney injury or even kidney disease but if you're worried it was well worth a visit for me to Mayo Clinic if you have the ability to go to a Mayo Clinic.
I hope that helps a little bit