Anyone reinstate Effexor (Venlafaxine) after 9 weeks off to taper more

Posted by Wayward Wynn @wynnaa, 2 days ago

Hello šŸ¤—
I was on Effexor (Venlafaxine) ER in January 2025, with my highest dose being 225 mg. I didn’t feel like I was getting much improvement with Venlafaxine, so I eventually tapered down gradually and slowly to 75 mg. Since the ER is a capsule, I asked my doctor to switch me to the IR so I could taper more even slower. Per her taper recommendation, I stayed at 25 mg for about 2 months, then went down to 18.75 mg for about 4 weeks and 12.5 mg for another 4 weeks and went down to 6.25 mg for another 4 weeks. Since I couldn’t cut the dose any lower, she recommended taking 6.25 mg every other day for about 2 weeks and then stopping. I stopped completely on June 4th.
I’m now 9 weeks off, and my doctor believes I’m still experiencing withdrawal symptoms. Since June 10th, I’ve felt keyed up much of the time, with adrenaline rushes, nervousness, rapid heart rate, and waves of anxiety. I’m also really sleepy, sluggish, and feeling wiped out. Even after sleeping 7–8 hours, I still wake up feeling like I haven’t slept. The symptoms continue from morning through the evening and are really affecting my quality of life. My doctor also prescribed Prozac to help with the withdrawal symptoms, but it didn’t help, so I stopped taking it. I take 10mg of propranolol in the morning to help with some of the anxiety symptoms.
I met with her last week and she said she did some research and also talked with some of her colleagues about my symptoms and they recommended that I reinstate at a very low dose and then taper much more slowly. One option she gave me was to restart with a 75 mg Venlafaxine XR capsule and count the beads, taking 10 beads (about 5 mg) to start. The plan would then be to gradually reduce the number of beads: 10 → 8 → 6 → 4 → 3 → 2 → 1 → 0, staying at each dose for 2–4 weeks or longer if needed. She also found a compounding pharmacy that can make liquid Venlafaxine IR, which would allow for even smaller dose reductions, but I am really hesitant to restart Venlafaxine. I worked hard to get off of it, and it wasn’t really helping the anxiety symptoms when I was taking it. I also don’t want to go through withdrawal again after I eventually stop.

Has anyone else been in this situation? Were you still having significant withdrawal symptoms 8–10 weeks after stopping Effexor (Venlafaxine)? Did you decide to reinstate and taper more slowly? If you did, did it help? If you decided not to reinstate, are you still having withdrawal symptoms, and have they started to improve with more time? What did you do that helped?

I’d really appreciate hearing from anyone who has been through something similar because I’m really struggling šŸ˜ž. Thank you

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Hi, not sure what all that stuff is ahead of my reply to you. šŸ¤”

REPLY
Profile picture for depressedbutnotdead @depressedbutnotdead

@wynnaa I went cold turkey, but was on 37.5, so a quick drop. I had been on it for quite few years however. It still sucked badly for about four weeks, then the symptoms receded for maybe two more before I didn't notice them anymore.

Brain zaps are what lasted the longest. Initially I had nausea and a lot of vertigo, but those resolved fairly quickly.

Over time Effexor slowly flipped me until it began making me suicidal, which is a known response with young people, but highly uncommon at my age (I was 59 when I stopped). I had only begun seeing a psychiatrist a few months prior to stopping, this after a trip to the psych ward and a late-in-life bipolar 2 diagnosis (I believe it's correct, as it explains pretty much my whole life). I needed to flat get off of it. I have repeatedly told friends and family if I hadn't stopped it when I did I would have followed through by now. I'm 100% convinced of this. I was tail-spinning fast.

That was two-and-a-half years ago.

I found a study right in that period that I've been unable to relocate. It was about a correlation between bipolar 2 patients, antidepressants, and suicide. I wish I'd bookmarked it. It was NIH or some other reliable source; I'm real careful about where I get medical information. It described the previous three years of my life up until then like a biography. Daily suicidal thoughts, uncontrollable anger, eating and sleep disorders, and on and on. The study noted that Effexor was the antidepressant most frequently associated with this reaction.

I actually found it on my own, realized that I'd likely found the cause, said "I'm done," and quit. My psychiatrist knew about the study but was skeptical that this was what had happened to me until I went in two weeks after quitting and she recognized immediately that my whole demeanor had shifted for the better. It's rare. She'd never seen it before. She has since told me she's using what she saw in me as a reference for what to look out for with future patients.

My therapist saw the sudden shift as well. I went from evasive and monosyllabic for months to being unable to shut up. One week I was as unreachable as ever. I'd quit the day before but didn't tell her. Two weeks later at my next appointment (I'd informed her by then that I'd stopped the medication and that my psychiatrist knew) I was prattling like crazy before I even sat down. The only time in my life I've ever made someone's jaw drop. She just stared at me stunned for almost a minute before she could think of something to say. From there on out (I'm still in therapy) I've been pretty talkative.

Saved my life getting off of that pill. I'm taking Lamotrigine now, which has kept me pretty stable.

Jump to this post

@depressedbutnotdead It really is worrying how meds can affect people. Very interesting reading what happened to you. Its great that you took control yourself....so many just go along with the Drs opinion, often ending tragically.

REPLY
Profile picture for cas2001 @cas2001

@depressedbutnotdead It really is worrying how meds can affect people. Very interesting reading what happened to you. Its great that you took control yourself....so many just go along with the Drs opinion, often ending tragically.

Jump to this post

@cas2001 thank you! I’m still working with my doctor to help me with these symptoms. She wrote me back today to say she believes I’m dealing with ongoing venlafaxine discontinuation symptoms, and some return/worsening of the anxiety and mood symptoms that venlafaxine had been treating 😢😢

REPLY
Profile picture for depressedbutnotdead @depressedbutnotdead

@wynnaa I went cold turkey, but was on 37.5, so a quick drop. I had been on it for quite few years however. It still sucked badly for about four weeks, then the symptoms receded for maybe two more before I didn't notice them anymore.

Brain zaps are what lasted the longest. Initially I had nausea and a lot of vertigo, but those resolved fairly quickly.

Over time Effexor slowly flipped me until it began making me suicidal, which is a known response with young people, but highly uncommon at my age (I was 59 when I stopped). I had only begun seeing a psychiatrist a few months prior to stopping, this after a trip to the psych ward and a late-in-life bipolar 2 diagnosis (I believe it's correct, as it explains pretty much my whole life). I needed to flat get off of it. I have repeatedly told friends and family if I hadn't stopped it when I did I would have followed through by now. I'm 100% convinced of this. I was tail-spinning fast.

That was two-and-a-half years ago.

I found a study right in that period that I've been unable to relocate. It was about a correlation between bipolar 2 patients, antidepressants, and suicide. I wish I'd bookmarked it. It was NIH or some other reliable source; I'm real careful about where I get medical information. It described the previous three years of my life up until then like a biography. Daily suicidal thoughts, uncontrollable anger, eating and sleep disorders, and on and on. The study noted that Effexor was the antidepressant most frequently associated with this reaction.

I actually found it on my own, realized that I'd likely found the cause, said "I'm done," and quit. My psychiatrist knew about the study but was skeptical that this was what had happened to me until I went in two weeks after quitting and she recognized immediately that my whole demeanor had shifted for the better. It's rare. She'd never seen it before. She has since told me she's using what she saw in me as a reference for what to look out for with future patients.

My therapist saw the sudden shift as well. I went from evasive and monosyllabic for months to being unable to shut up. One week I was as unreachable as ever. I'd quit the day before but didn't tell her. Two weeks later at my next appointment (I'd informed her by then that I'd stopped the medication and that my psychiatrist knew) I was prattling like crazy before I even sat down. The only time in my life I've ever made someone's jaw drop. She just stared at me stunned for almost a minute before she could think of something to say. From there on out (I'm still in therapy) I've been pretty talkative.

Saved my life getting off of that pill. I'm taking Lamotrigine now, which has kept me pretty stable.

Jump to this post

@depressedbutnotdead Thanks for responding. I am 59 years old too. I did not have any of what you had while on Venlafaxine for 19 months, but since I stopped taking it 10 weeks ago, I am now dealing with uncontrollable anger, irritability, sadness, anxiety, feeling wiped out, and short tempered. I refuse to restart it via the hyperbolic method of counting beads and tapering slowly at 5mg. My doctor respects this and isn’t pushing me to try it. I messaged her today and she believes I am still dealing with ongoing venlafaxine discontinuation symptoms, and some return/worsening of anxiety and mood symptoms that venlafaxine had been treating. I have an appointment with her in 2 weeks and she said if I want, I can try a different antidepressant with what she describes as a ā€œmuch gentler discontinuation profile,ā€ starting at a very low dose and making slow adjustments.

My previous doctor prescribed Lamotrigine when I was on 75mg of Venlafaxine but I started having daily rapid heart beats and it became bothersome so I stopped taking it. I’m glad things are pretty settled now for you šŸ¤—

REPLY
Please sign in or register to post a reply.