Anyone had a decipher test done, and if so, how did the results impact

ADT option and duration. Most importantly it will give you a somatic idea of the aggressiveness of the tumor, so might change a decision between radiation and surgery.
When you get the decipher results ask for the grid. The grid will tell you which genetic mutations were measured. and their association in the test population.
best luck

I have a 4+3 and a 3+3. My Decipher was .84 and that tripped the trigger to add ADT to my SBRT. Six months of Orgovyx. Get the test if you can.

rkurtzjr: I had both the decipher and prolaris test. Decipher has a greater sample size. It measures genomic characteristics of the tumor and is independent of NCCN.org risks that doctors and patients look at.

The doctors do use this test to help determine potential aggressiveness and modes of treatment. My psa was 10.2 at age 69 but ended up with targeted narrow margin radiation with 5 treatments but no androgen therapy even though NCCN guidelines suggest it with a 10.2 psa. My last 3 blood tests had solid declining psa and I was treated in Jan/Feb 2023.

The Decipher test also helps to have another opinion outside your institution while at the same time giving one a little more confidence in the decisions one may make.

I also had the MyRisk hereditary cancer genetic test (Myriad Genetics), more for my children, daughter AND sons. If the test had shown a clinically significant result for a brca gene, then I would have alerted my daughter for potential breast cancer and so on ... for 50 tested genes.

I was Gleason 3+4 at no more than 30% in 2 of 12 biopsy samples. My urologist and I were leaning towards active surveillance until the Decipher results came back indicating my cancer was aggressive and highly likely to metastasize. I ended up having 39 rounds of VMAT last summer, but no ADT. My pre-treatment PSA of 4.63 has dropped to 1.66, then 1.30, post-treatment.

bensl, is there an advantage to having the Polaris after or instead of Decipher? What did you get from Polaris?
Thanks

Easiest decision I ever made, while still deciding RP vs. radiation. They use existing material from your biopsy and all you need to say is 'do it'. My urologist was, as you might expect, advocating surgery, but, when the intermediate 0.57 Decipher Grid came back, he changed his recommendation to neutral and I went with ADT/Cyberknife/EBRT due to a majority of my Drs. (I consulted 6) saying the chemical recurrence rate would be lower.

Any helpful data you can get, with zero pain or expense, is a big YES in my book.

@gently: I had actually taken the Prolaris Test first, but then when I talked to my radiation oncologist at Cornell Weill, and then with the radiation oncologist in Orlando, they both suggested the decipher because of the sample size, and felt that it was more accurate. However, my results were relatively the same with both tests.

If you want a copy of both my results, for comparison purposes, let me know. I will just take out my name, address…. Just dm me.

Did your sbrt have the daily adaptive radiation technique?

Does anyone know if the Decipher Test can be done with blood only? Had prostate removed almost 5 yrs ago and no genetic testing was done. Had Gleason 4+3 on practically entire right lobe; left and median totally normal. PSA has been rising and is now .15....next PSA test in a week at Sloan Kettering. If it hits .2 they are scheduling PSMA scan but I am more concerned with the duration of hormone treatment which would also be necessary. Don't mind 6 months but don't think I can hack 12-18 months....ugh!! Many thanks in advance! AL

@rkurtzjr SBRT in my case was a 'boost' therapy at UCSF involving treatment sessions 950 cGy x 2 only. I'm not sure if they updated the mapping, but, doubt that given the small number of fractions. Cyberknife treatments preceded VMAT EBRT 180 cGy x 25 at Stanford. I chose Cyberknife over HDR brachytherapy done by Dr. Roach, who published a report comparing efficacy, since it was far less invasive, among other reasons.