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Anyone diagnosed with mitochondrial dysfunction?
The sequencing of my genome revealed mutations in my FBXL4 and SDHB genes, and these mutations impair the function of the mitochondria in my nerve cells. Mitochondria are the "power plants" of cells. So, the theory is that mitochondrial dysfunction over time causes the death of nerve cells. Anybody else heard that their mitochondria are impaired or dysfunctional? In theory, gene therapy could remedy the problem, but I think that's probably a ways off.
Thanks.+
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Yes, but I believe that my mitochondrial damage occurred before my neuropathy. I was poisoned by a fluoroquinolone antibiotic, as are tens of thousands of others. Neuropathy is a common symptom of fluoroquenolone toxicity.
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5 Reactions@margaret10, You might want to watch the video by Dr. Terry Wahls in this discussion which I think might tie some of the pieces together for possible explanations.
-- Food for Thought - Why so many Autoimmune Diseases?
https://connect.mayoclinic.org/discussion/food-for-thought-why-so-many-autoimmune-diseases/
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3 ReactionsAlthough I do not have an autoimmune disease (like Dr. Wahl's MS), I do have two mutations that have produced mitochondrial dysfunction, which seems to be a culprit in a number of diseases. My mito doctor recommended a number of supplements (creatine, vit E, alpha-lipoic acid, TruNiagen, coQ10) that are anti-oxidants or otherwise work to bolster mitochondrial function. So I'm thinking I should just follow Dr. Wahl's advice to go on supplements plus an anti-oxidant diet to maximize mitochondrial function. Thanks again!
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1 ReactionI think I got mitochondrial disorder after Cipro drug too. I have only one pathological gene for MCADD but I experience severe hypoglycemia and chest pain from palpitations at night.
From simvastatin, taken 7 months, I have mitochondrial dysfunction. The simvastatin-caused lack of CoQ10 at the start of the mevalonate pathway and thus the diminished production of ATP is well-known. Dr. John Thyfault's papers on exercise with simvastatin was cited in the New York Times in 2013.
I called Mayo Clinic way back then, when I found out about this issue.
How could I, a lowly owner of a couple of outdoor sports stores, have gotten a jump on the whole Mayo Clinic?
Is there anyone else here with a similar issue. I know what I should have done: I should NOT have given into my doctors (plural, because I did seek a second opinion); I should not have followed their advice regarding exercise, which was "do what you always do; and I should have taken CoQ10 with or before I started simvastatin.)
Actually, if I'd know that Merck held (but never used!) a patent on administering statin with CoQ10, I'd never have taken the drug. And had I know about the SCTUS decisions of 2011 and 2013 regarding litigation vs generic drugs, I'd have insisted on Zocor and I could have litigated. Sickening....
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3 ReactionsMitochondrial dysfunction, Mitochondrial damage--however one wants to put it, the Mayo Clinic should have this topic as a category. I'll be updating StatinStories.com in two or three weeks, but photos are available now.
How many people have been put on a statin drug since 1980 in the USA? Millions, no?
As one cardiologist (I believe his name was Dr. Nadir Ali) humorously put it in one of his videos, "if the medical profession does not take the lead on statins, we're going to get buggy-whipped."