Anybody with NSCLC with EGFR exon 21 L858R mutation response to TKIs?
My wife was just diagnosed with Non Small Cell Lung Cancer (Adenocarcinoma) sensitive to EGFR tyrosine kinase inhibitors [TKI]
(exon 21 L858R mutation). She never smoked.
It has been suggested to use osimertinib(Tagrisso).
Thorasic Surgeon seems to rule out surgery as he would have to remove middle and lower right lung and thinks there would be a resulting breathing problem.
Oncologist asked for biopsy of lower right lung to see if cancer is same as already tested middle right lobe.
Could a TKI reduce the cancer enough to make a safer excision?