Anybody currently/recently on Carboplatin, Alimpta, Keytruda?

Posted by toniparks @toniparks, Aug 5 8:27am

Hi! I’m Toni. I was diagnosed with Stage IV NSCLC Adeno in Feb 2018. After 6 years stable and 1 year NED, the cancer has returned. I started Carbo/Alimpta/Keytruda almost two weeks ago. The side effects have been horrific. Last time, I didn’t have Keytruda, and blamed them on the Carbo. I couldn’t do Alimpta maintenance due to toxicity. I’m thinking this may be more due to Alimpta vs Carbo. Anybody? Thanks.

Interested in more discussions like this? Go to the Lung Cancer Support Group.

hi @toniparks - welcome to Mayo Connect. sorry to hear you've had recurrence and that you're having to do chemo again. I don't have experience with those meds, but you can find other discussions on here about those. Alimpta is the brand for permetrexed and sometimes you can find more comments by searching on the generic medication names.
like this one:
https://connect.mayoclinic.org/discussion/carboplatin-plus-permetrexed/

REPLY

This was my most recent treatment which ended a year ago May due to cardiac issues. I am stable after 4 rounds of treatment and 3 maintenance treatments.

REPLY

Welcome @toniparks , I'm sure it's deflating to be struggling with side effects to this degree. Has your cancer center had suggestions, other than holding treatments? It sounds brutal.

REPLY
Profile picture for denzie @denzie

This was my most recent treatment which ended a year ago May due to cardiac issues. I am stable after 4 rounds of treatment and 3 maintenance treatments.

Jump to this post

@denzie thank you. Did you have side effects? Did it cause your heart issues? Wonderful in being stable! Thank you!!

REPLY
Profile picture for Lisa, Volunteer Mentor @lls8000

Welcome @toniparks , I'm sure it's deflating to be struggling with side effects to this degree. Has your cancer center had suggestions, other than holding treatments? It sounds brutal.

Jump to this post

@lls8000 hi Lisa! Yes, I have a new plan going forward on my next treatment. Thank you!!

REPLY
Profile picture for toniparks @toniparks

@denzie thank you. Did you have side effects? Did it cause your heart issues? Wonderful in being stable! Thank you!!

Jump to this post

@toniparks can't be certain what lead to the heart issues. It can take years for treatment related heart issues to develop. In the past I had radiation on my left lung and a few years later for a left side breast cancer.

Neither my cardiologist or my oncologist could say with any degree of certainty that it was the carbo, Alimta, or keytruda. It could be none of the above or all of the above. I'm planning to consult with a cardio-oncologist when or if I need treatment again.

REPLY

Sorry to hear that Toni. My husband was on it until March this year but stopped due to progression and not helping. What kind of side effects are you facing? We learned that his nausea meds were causing them more than keytruda. After switching nausea med from Odansetron to Olanzapine it worked better.

REPLY
Please sign in or register to post a reply.