I have a family member with Bipolar Disorder and Asperger’s, they have been on Seroquel and Lithium for 20 years and Abilify for 12. Never have they been “meltdown free”, but the episodes were much less frequent and severe. Recently they are coming more often and much more aggressive, and it began with a major life disappointment and horrible low mood taking over and feeling stuck in life and not knowing how to/or able to navigate their way out. Our family is very supportive and doctors are supposedly experts in bipolar. I have never seen them so low and finding absolutely no interest in things that usually inspire. Complaints are that their brain is dull/numb and can not think and the smallest thing has been setting them off in truly unreasonable anger outbursts so bad police have had to be called. First time we went to the hospital who practically talked them out of wanting to be admitted for help and ended by saying they had no bed. After that experience the interest in being hospitalized for help has vanished. Do any of you have experience with these symptoms and how/where have you received help? What has worked for you?