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3 years ago ANA 1:80 now my ANA 1:640 help please

Posted by midd0nite1blu2 @midd0nite1blu2, Nov 22, 2025

I had an ANA test 4/2022. Results showed high Titer of 1:80, speckled pattern. I was weak, always tired, sleeping a lot, all over pain. I could do nothing. The cascade showed negative for the 11 things tested. Fast forward to a repeat ANA 11/2025 this one says titer of 1:160 speckled A pattern, AND a titer of 1:640 with a homogenous A pattern. I checked all my medications to see if any could cause this and nothing does. With the recent ANA I also had a UTI. And I have kidney issues. Can anyone please give me insight as to if I need to follow up with a rheumatologist? I have an extremely high deductible and if I can pass on going, I would rather. Same symptoms as before, very tired, all over pain, mainly low back and hips, my tongue feels swollen (?) and my mouth seems dry. I’m always told I am dehydrated even though I drink plenty of water (it’s my go-to)
Thank you all for any insight you may share.

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midd0nite1blu2 | @midd0nite1blu2 | Dec 2, 2025
In reply to @nifty50co "I agree with finding a GOOD Rheumatologist. I also had a lot of luck seeing an..." + (show)
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I agree with finding a GOOD Rheumatologist. I also had a lot of luck seeing an immunologist. For dry mouth, I use oraCoat tablets. Good luck!!

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@nifty50co thank you!

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midd0nite1blu2 | @midd0nite1blu2 | Dec 2, 2025
In reply to @diverdown1 "When I got Long COVID, my ANA titer was 1:80 speckled as well. I tested negative..." + (show)
Profile picture for diverdown1 @diverdown1

When I got Long COVID, my ANA titer was 1:80 speckled as well. I tested negative for Sjogrens, HIV, Lupus, Lyme's and others. I do have inflammation and EBV was reactivated. I felt like I had a UTI and lived on AZO. It was not a UTI. It was symptoms of Interstitial Cystitis. I started drinking only water and that helped. That went away as well. PEM and chronic fatigue are the worst symptoms and tinnitus. I can't feel temperature sometimes in the mornings as well as not being able to taste anything, but that eventually goes away. All of this boils down to inflammation and I am starting to think that it has to do with stress (fight or flight adrenaline and cortisol) for many years. After I got Covid, twice, my body just said STOP. Anyway, I am still fighting and I take medications to help with some symptoms. I am better than I was 3 years ago for sure. Hang in there.

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@diverdown1
Oh my goodness, I’m glad you are recovering, albeit slowly, still a step forward is better than backward.
I’m still waiting to see if I’ve been accepted with a less expensive insurance and then if so, in January I will make an appointment with a rheumatologist.
Thank you for your response. Blessings!

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Kitten92 | @kitten92 | Mar 18 1:27pm

I recently had a positive ANA with a titer of 1.640. No referral yet so no indication of what is causing this. Severe dry mouth is what prompted the test. That has corrected itsself. I am tired all the time but nothing else has presented itself. I have heard it takes alot of negative testing to get to the positive testing so we have to be patient.

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taylor05 | @taylor05 | Mar 19 9:55am

I'm sorry to all of you.. I tested positive first time and they sent another set of blood bikes off to a lab in California and positive again. That was in 2020 after vaccines for covid. Since then I have Connective Tissue Disease. Sleraderma, Sjögren's syndrome, Raynouds antiphospholipid syndrome and they think GPA , but will be tested for it. I have had several ischemic strokes and have pulmonary 🫁 fibrosis.. Keep yourselves checked and hopefully help given early for all they can give you. No cure though for any of it!! I see a neurologist in John Hopkins for small blood vessel issues with the strokes. I also get headaches and he gives me a med for it. Helps a lot!

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fairn | @fairn | Mar 19 11:38am

Your symptoms and ANA could indicate a few different autoimmune diseases. Sjogren's will cause extreme fatigue, dry mouth and eyes, joint pain and impacts organs like the kidneys. The testing usually begins with a basic panel to screen several common autoimmune diseases and is simple to do, just a blood draw. Many of the tests will not register positive until a certain amount of damage has been done, which makes it hard to catch things early. Some tests will not come back positive but you may still have the disease, that's considered
sero-negative' and Sjogren's, Rheumatoid Arthritis and others can fall into that category. Since you have a positive ANA a good rheumatologist should look closely at your symptoms (inflammation, dry mouth, joint pain) and treat those, regardless of negative results for specific autoimmune tests. I would encourage you to sit down and list all the the health issues/symptoms in your history- don't leave anything out no matter how unrelated it may seem. I was floored by how many seemingly unconnected illnesses and health problems I've had over the years were actually a result of having autoimmune disease. Take the list with you to the rheumatologist, it can be very helpful towards what to test and to look for. I currently have Sjogren's, RA and tested positive for the HLA-b27 gene; my siblings have this gene as well and have had major back surgeries for Ankylosing Spondylitis. Be your own advocate, listen to your gut and best of luck to you!

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