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10 months after brachytherapy seeing a slight increase in PSA
I had brachytherapy in July of 2025 when my Gleason went for 6 to 7 (3+4) and PSA rose to 10. Since then I've been getting PSA checked every three months and in March of this year it had dropped to 0.331. My last PSA showed an increase to 0.407. Is this any cause for concern? I have an appointment with the urologist next week and he was upset that I did not originally do brachy, radiation and ADT even though three oncologists told me this would have been overkill.
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You really need to wait for a few more tests to see what the PSA will do. It could be insignificant it could be signs that it’s starting to come back again, but it may just go back down.
Gleason 3+4 is usually very slow growing. Were there any other aggressive issues in your biopsy that you didn’t mention? If not, then this rise may mean very little. What is important is your doubling time not just a single result.