1. < Neuroendocrine Tumors (NETs)
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01/29/2026 I had Net removed at hepatitis portis. Cga was 3886.

Posted by stevenkos @stevenkos, 1 day ago

Dr tells me not to worry to much about Cga. After surgery labs, Cga went down to 518. Now After 4 months Cga up to 1356. I'm due for another DOTATATE PET scan head to mid thigh. The first one before surgery didn't show any uptake. I am concerned about another Net. Anyone else have this reoccurring tumor? Thanks, any comments appreciated.

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mcharlesfrancis | @mcharlesfrancis | 1 day ago

can understand why that increase would make you nervous. A rise in CgA from 518 to 1356 certainly gets your attention, but it's encouraging that your doctor is not overly concerned and has ordered another DOTATATE PET scan.

One thing I've learned from talking with NET patients is that Chromogranin A can be influenced by many things besides tumor growth, including medications such as proton pump inhibitors, kidney function, inflammation, and other medical conditions. That's why many NET specialists place more emphasis on imaging and overall trends than on a single CgA value.

The fact that your first DOTATATE PET scan showed no uptake is also an important piece of information. Hopefully the upcoming scan will provide some clarity.

As for recurrence, many NET patients do experience recurrence after surgery, while others have elevated tumor markers for years without clear evidence of active disease. That's one reason these scans are so important.

Please keep us posted on what the DOTATATE PET scan shows. Wishing you good results and some peace of mind while you wait.

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stevenkos | @stevenkos | 23 hours ago
In reply to @mcharlesfrancis "can understand why that increase would make you nervous. A rise in CgA from 518 to..." + (show)
Profile picture for mcharlesfrancis @mcharlesfrancis

can understand why that increase would make you nervous. A rise in CgA from 518 to 1356 certainly gets your attention, but it's encouraging that your doctor is not overly concerned and has ordered another DOTATATE PET scan.

One thing I've learned from talking with NET patients is that Chromogranin A can be influenced by many things besides tumor growth, including medications such as proton pump inhibitors, kidney function, inflammation, and other medical conditions. That's why many NET specialists place more emphasis on imaging and overall trends than on a single CgA value.

The fact that your first DOTATATE PET scan showed no uptake is also an important piece of information. Hopefully the upcoming scan will provide some clarity.

As for recurrence, many NET patients do experience recurrence after surgery, while others have elevated tumor markers for years without clear evidence of active disease. That's one reason these scans are so important.

Please keep us posted on what the DOTATATE PET scan shows. Wishing you good results and some peace of mind while you wait.

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@mcharlesfrancis
Thank you for the encouraging response. I am however stopping the 40mg omeprazole will be 2 weeks on 06 /13. prior labs, Liver and kidney functions, enzymes are normal. Ast /Alt are normal. Thanks @mcharlesfrancis. Will give a heads up after DOTATATE PET scan.

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Turkey, Volunteer Mentor | @tomrennie | 23 minutes ago
In reply to @stevenkos "@mcharlesfrancis Thank you for the encouraging response. I am however stopping the 40mg omeprazole will be..." + (show)
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@mcharlesfrancis
Thank you for the encouraging response. I am however stopping the 40mg omeprazole will be 2 weeks on 06 /13. prior labs, Liver and kidney functions, enzymes are normal. Ast /Alt are normal. Thanks @mcharlesfrancis. Will give a heads up after DOTATATE PET scan.

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@stevenkos Hi and welcome to Mayo Connect. I am curious. Why did you stop the omeprazole?

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