can understand why that increase would make you nervous. A rise in CgA from 518 to 1356 certainly gets your attention, but it's encouraging that your doctor is not overly concerned and has ordered another DOTATATE PET scan.

One thing I've learned from talking with NET patients is that Chromogranin A can be influenced by many things besides tumor growth, including medications such as proton pump inhibitors, kidney function, inflammation, and other medical conditions. That's why many NET specialists place more emphasis on imaging and overall trends than on a single CgA value.

The fact that your first DOTATATE PET scan showed no uptake is also an important piece of information. Hopefully the upcoming scan will provide some clarity.

As for recurrence, many NET patients do experience recurrence after surgery, while others have elevated tumor markers for years without clear evidence of active disease. That's one reason these scans are so important.

Please keep us posted on what the DOTATATE PET scan shows. Wishing you good results and some peace of mind while you wait.