Hello. Yes the joint pain did go away. I can't say exactly how long it lasted and to be fair, I do have some joint discomfort due to the osteoarthritis anyway. I just thought it was more severe in the major joints, with generalized aching for something like 2 -3 months. I'm good now and facing another infusion in May. I'm still not sure if I'm going to do it. I'm doing some research on supplements, vitamins, etc. Good luck with whatever you decide to do.