1. < Prostate Cancer

Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

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digger | @digger | Dec 3, 2023
In reply to @robert570 "I had the Pluvicto treatment at University Hospital in Cleveland, Ohio. I had 3 infusions. After..." + (show)
@robert570

I had the Pluvicto treatment at University Hospital in Cleveland, Ohio. I had 3 infusions. After the 3rd I had them stop it. My PSA started out at 1.56 and ended up at 20.83 after the 3rd. Pluvicto works for most men but it didn't for me. I had no side effects and felt pretty good, but the doubling of the PSA through me a curve ball. I would like to know if anyone else has had this problem. I'm back on Jevtana with Carboplatin chemo now and it's hitting me a little hard. My PSA leveled off, but it's slowly starting to rise again. I will be getting a PSA test on December 5th, fingers crossed. It now stands at 22 after falling back around 19. It's been 10 years battling this disease. My PSA has been as low as .18 to a high of 2.56 but Pluvicto broke the mold and sent it soaring. Good luck!

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Have you had Xofigo?

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1 reply
robert570 | @robert570 | Dec 4, 2023
In reply to @digger "Have you had Xofigo?" + (show)
@digger

Have you had Xofigo?

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No, that's the only one. I'm going to ask my oncologist.

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amee | @amee | Dec 22, 2023

For my dad he has stage 4 prostate cancer. He has done 6 docetexel chemi cycle. Now on enzalutamide but one of the Oncologist has suggested this treatment after chemo coz even after chemo he has few cancerous spots on his spine. I have been told it is right time for PRRT Lu 177 treatment but I am not sure what to do before chemo his PSA was 14.75 after chemo it has deceresed to 0.63 and after 1 month of enzalutamide it was 0.12. So I really needs guidance whether to go for PRRT lu 177 or not.

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Dec 26, 2023
In reply to @amee "For my dad he has stage 4 prostate cancer. He has done 6 docetexel chemi cycle...." + (show)
@amee

For my dad he has stage 4 prostate cancer. He has done 6 docetexel chemi cycle. Now on enzalutamide but one of the Oncologist has suggested this treatment after chemo coz even after chemo he has few cancerous spots on his spine. I have been told it is right time for PRRT Lu 177 treatment but I am not sure what to do before chemo his PSA was 14.75 after chemo it has deceresed to 0.63 and after 1 month of enzalutamide it was 0.12. So I really needs guidance whether to go for PRRT lu 177 or not.

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Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who can share their experiences with Pluvicto (lutetium Lu 177).

As for deciding whether to start this treatment now or when for your dad, that is a tough one for fellow patients to answer. It sounds like you need more information from his oncologist to help your decision-making. I would ask questions like:
- With his PSA level responding well to current treatment, why is now a good time to include or switch to Lu 177?
- What are the side effects?
- What are the benefits?
- What would happen if he chose not to start this treatment yet? Never?
- Can he take a break or treatment holiday if treatment side effects are too much?

When do you speak with the oncologist to make your decision?

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3 replies
robert570 | @robert570 | Dec 27, 2023
In reply to @colleenyoung "Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who..." + (show)
@colleenyoung

Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who can share their experiences with Pluvicto (lutetium Lu 177).

As for deciding whether to start this treatment now or when for your dad, that is a tough one for fellow patients to answer. It sounds like you need more information from his oncologist to help your decision-making. I would ask questions like:
- With his PSA level responding well to current treatment, why is now a good time to include or switch to Lu 177?
- What are the side effects?
- What are the benefits?
- What would happen if he chose not to start this treatment yet? Never?
- Can he take a break or treatment holiday if treatment side effects are too much?

When do you speak with the oncologist to make your decision?

Jump to this post

I WAS RESPONDING WELL TO CURRENT TREATMENT, THEY STOPPED IT TO TRY PLUVICTO AND MY PSA WENT FROM 1.56 TO 20.83 I STOPPED IT AFTER 3 ROUNDS, SCHEDULED FOR 6. This doesn't mean it will fail for you and for most it works. Just be careful and monitor things. By the way I was on Jevtana and Imback on it again. MY PSA is slowing. Good luck!

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dwpoole | @dwpoole | Dec 27, 2023
In reply to @colleenyoung "Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who..." + (show)
@colleenyoung

Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who can share their experiences with Pluvicto (lutetium Lu 177).

As for deciding whether to start this treatment now or when for your dad, that is a tough one for fellow patients to answer. It sounds like you need more information from his oncologist to help your decision-making. I would ask questions like:
- With his PSA level responding well to current treatment, why is now a good time to include or switch to Lu 177?
- What are the side effects?
- What are the benefits?
- What would happen if he chose not to start this treatment yet? Never?
- Can he take a break or treatment holiday if treatment side effects are too much?

When do you speak with the oncologist to make your decision?

Jump to this post

I finished 6 lu177 treatments in November. I’m still on lupron and zytiga. My psa has been undetectable for about 6-8 months. I was in a clinical trial to test this triplet therapy. It will be hard to determine which treatment gets credit for my good outcome. My bone scans with the most recent scan in December show fewer bone Mets . I am told the remaining areas of uptake are from bone healing and not the tumors. I’m told that I am in remission and my outcome at this point is the best that could be hoped for. Hopefully this clinical trial will help determine how much early lu177 treatment was responsible.
It is hard to distinguish what caused my SE but fatigue is slightly better after finishing Lu 177 so I suspect it caused additional fatigue. But it’s manageable. It left me with dry mouth and metallic taste but that is getting better.
My hope is that ADT weakened the Mets so that Lu177 could finish them off.

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1 reply
rxharleydude | @rxharleydude | Dec 28, 2023
In reply to @dwpoole "I finished 6 lu177 treatments in November. I’m still on lupron and zytiga. My psa has..." + (show)
@dwpoole

I finished 6 lu177 treatments in November. I’m still on lupron and zytiga. My psa has been undetectable for about 6-8 months. I was in a clinical trial to test this triplet therapy. It will be hard to determine which treatment gets credit for my good outcome. My bone scans with the most recent scan in December show fewer bone Mets . I am told the remaining areas of uptake are from bone healing and not the tumors. I’m told that I am in remission and my outcome at this point is the best that could be hoped for. Hopefully this clinical trial will help determine how much early lu177 treatment was responsible.
It is hard to distinguish what caused my SE but fatigue is slightly better after finishing Lu 177 so I suspect it caused additional fatigue. But it’s manageable. It left me with dry mouth and metallic taste but that is getting better.
My hope is that ADT weakened the Mets so that Lu177 could finish them off.

Jump to this post

I, too, am in my 4th /of 6 doses of Docetaxol to hopefully weaken the bone mets & will be starting Pluvicto after that. Hoping and praying it works well for me! Not too many options left after that😷🥺

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kbrz | @kbrz | Dec 28, 2023
In reply to @colleenyoung "Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who..." + (show)
@colleenyoung

Hi @amee, I'm tagging fellow members like @leebeth @ncoic @spryguy @robert570 @nores717 @dwpoole @dwpoole @eercat81 who can share their experiences with Pluvicto (lutetium Lu 177).

As for deciding whether to start this treatment now or when for your dad, that is a tough one for fellow patients to answer. It sounds like you need more information from his oncologist to help your decision-making. I would ask questions like:
- With his PSA level responding well to current treatment, why is now a good time to include or switch to Lu 177?
- What are the side effects?
- What are the benefits?
- What would happen if he chose not to start this treatment yet? Never?
- Can he take a break or treatment holiday if treatment side effects are too much?

When do you speak with the oncologist to make your decision?

Jump to this post

I was not allowed to start Pluvicto until Chemo had been tried and failed or tolerating was too difficult. I'm 4 weeks out from Pluvicto round # 1 now. No nausea, but my appetite is less demanding. Fatigue is a come and go thing, I try to keep my same schedule.
Thank you everyone for posting to allow others to get prepared and or make decisions.
Healthy Happy New Year To All...............

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feralcats | @feralcats | Dec 29, 2023

what is Pluvicto. how is it admistered

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ronc320403 | @ronc320403 | Dec 30, 2023

Question?
I've been researching this drug and it sounds very exciting. Please advise if my understanding is correct.
This drug works in direct contradiction of other drugs, such as Lupron with respect to testosterone, correct? It is prescribed only after the Lupron type drugs have failed or quit working? Thank you for any help with this!

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