Welcome to Connect, @weissmntc. You’ve just been handed a new diagnosis of Waldenstrom Macroglobulinemia. I’m sure you have a ton of questions about this blood condition along with the new treatment you’re about to begin. We have a number of members in the forum who have also been diagnosed with WM.

This discussion might be helpful with @ejrquast @aann @nsh regarding
Waldenstrom macroglobulinemia: What can I expect with chemo?
https://connect.mayoclinic.org/discussion/waldenstrom-macroglobulinemia-recently-diagnosed/

Another current discussion, though it dates back to 2012, is still active. You can reverse the order of discussions in the little option box under the opening statement:
Waldenström's Macroglobulinemia
https://connect.mayoclinic.org/discussion/waldenstrms-macroglobulinemia/

If you’re interested in learning more about your condition I’ve found a few links for you regarding WM.

https://www.mayoclinic.org/diseases-conditions/waldenstrom-macroglobulinemia/symptoms-causes/syc-20359967
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International Waldenstrom's Macroglobulinema Foundation http://www.IWMF.com
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https://www.verywellhealth.com/what-is-waldenstrom-macroglobulinemia-2252362
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https://www.lls.org/sites/default/files/2021-07/FS20_Waldenstrom_FactSheet_2021.pdf

Brukinsa and Rituximab is a pretty standard combination of treatments for many types of blood cancers/conditions. It’s not just for WM. There are many members in our Blood Cancer Support group (such as @badnewsforme who shared their experience in the comment above) who have taken this course of treatment. Here’s one of the discussions that will be relevant for you:

Rituximab & Bendamustine
https://connect.mayoclinic.org/discussion/treatment-for-mzl/

Hopefully I haven’t overwhelmed you with information. But knowledge is power and it’s often helpful to learn as much as you can so you are able to make informed decisions about treatment.

Were you having symptoms that lead you to finding the diagnosis or was this found in a routine physical?