Welcome, @djf31. It is all too common to dismiss symptoms as a sign of getting older and hard to distinguish the difference when living with a chronic conditions, especially Waldenstrom macroglobulinemia where fatigue is one of the top symptoms.

I'm tagging @ejrquast @sagenest @sstouten @psue4 @squidlee and others who live with WM and can share their experiences.

You mention that the tired spells or the shortness of breath don't last long. Do you notice a pattern? Do they happen at specific times of the day or are triggered by certain activities?

It sounds like it could be your heart. I had the same symptoms and was diagnosed with AFIB and had an ablation procedure on my heart. I feel much better and have more energy. I was diagnosed in 2009 and have no symptoms of WM except it always shows in my blood work.