Thank you so much for your comments. Where did you order the CYP test from as the results would be very interesting? My gradient dropped from over 100 to 19 after one month on 5mg of mavacamten. I was decreased to 2.5mg and have sustained my low gradient at 17 after month 2. I have had “known” HCM for over 10 years and had been relatively asymptomatic on metoprolol (with a gradient of 30). However, this year (a few months after I acquired Covid) my gradient and symptoms (SOB and fatigue which is new) increased significantly. Now I wonder if I have long covid instead since my gradient is so low and I’m still symptomatic?? I will stay the course for a few more months and hope more improvement is to come. I agree, we have to be our own advocate and so much more research is needed for HCM.