Anybody else have a different experience with the Big 3 the 2nd time?

I tried Rifampin 2 separate times. I felt like I had the worst case of the flu after three days on it. I stopped it and my ID doc wanted me to try it again a month later to make sure it wasn’t the flu. After the first dose I got the flu symptoms again. It took about 2 weeks to feel back to normal.(whatever normal is these days). I was then put on levequin and now off that after 5 months because I have numbness in my toes and all joints hurt. I’m only taking Azithromycin and Ethambutol 3xw… no clue what’s next till Dec. the up side in this is I am not coughing much at all.

That is one nasty drug. I took it for over 13 months with the other two and for some reason developed a reaction to it. It put me in the hospital twice this year. After the second time with elevated heart rate of 150 and oxygen level dropping to 77 and a four day stay at hospital, I took my self off all of the drugs. I will never ever go back to the I.D. doctor again. I tried to tell him and he wouldn't listen. He almost killed me. I informed my Pulmonary Doctor, that he was in charge, because I wouldn't go back to that I.D. doctor again. It is well documented the side effect of the drug and the I.D. doctor should have known better.

I went back on the big 3 a second time on the assumption Mac has returned. After 6 months of testing, referrals, etc I was diagnosed with aspergillus, not Mac. Other infections seem to follow Mac treatment. My second big 3 had no effect on aspergillus, so a change in treatment was made.

Do you mean the levaquin was nasty?
Or the rifampin?

Rifampin