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Treatment for AML Relapse

Blood Cancers & Disorders | Last Active: May 21 9:25am | Replies (6)

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@timt347

I am responding to the two drugs (V. and A. for short). The problem with them is that at some point the leukemia cells develop resistance and the drugs stop working.

There may indeed be a clinical trial of some type in my future. I would do it just to advance the state of research if I had no treatment options.

In "New Scientist" magazine within the past year I happened across an article about CAR-T cells and leukemia. (See https://www.newscientist.com/article/2350806-experimental-crispr-technique-has-promise-against-aggressive-leukaemia/ from December 2022.) It looked promising for some leukemias, but not others. However, it seemed to be an active area of research as researchers sought to overcome obstacles.

Your post caused me to look for and find the following article. I used Google to search for "CAR-T cell therapy for AML".
https://www.cancer.gov/news-events/cancer-currents-blog/2023/universal-car-t-cell-blood-cancer
Title: Researchers Develop a Potential “Universal” CAR T-Cell Therapy for Blood Cancers

The article is on a blog from the National Cancer Institute. I will read it.
It is from September 27th of this year, so it is very recent. If it looks at all promising I will forward it to my doctor.

My transplant specialist did not think that I was a good candidate for a second bone marrow transplant, and he was not crazy about any type of immunotherapy for me. We will see what happens.

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Replies to "I am responding to the two drugs (V. and A. for short). The problem with them..."

Hi Tim, I just saw this study released on a new potential AML therapy for relapsing patients. It appears to still be in Phase l trial. I have another friend who was interested in this article and thought you might like to see it too if it wasn’t already on your radar.
https://news.vumc.org/2024/01/04/potential-aml-therapy-induces-leukemic-stem-cell-death/
I hope you have a Happy, Healthy and uneventful (medically speaking) new year! ☺️