@reillyg1013, @chucklesg, @euscsey and all...I was on heavier medications for multiple reasons, diagnoses, and years. I'm off it all now...off gabapentin, Lyrica, oxycodone, heavy ibuprofen, alprazolam, Cymbalta, Robaxin, and more...I continue to take Cymbalta for Fibromyalgia and it's excellent help for me. Robaxin is wonderful. Alprazolam I'm reducing but will continue. I have found the regimen I laid out in my earlier message is excellent for my needs, and helps me lose the RLS discomfort and symptoms.

I think the magnesium, Proferrin Clear, Requip, Robaxin, melatonin, CBD, and Kenalog cream as needed, on my legs, feet, and lower back and the occasional Bumex to control my edema caused by Primary Aldosteronism. Edema causes my RLS symptoms to flare so I have quite the balancing act to keep it all under some control. I'm happy to say it's helping and at the moment, I'm pleased with the improvement I'm experiencing. I occasionally use a prescription magnesium cream or Voltaran, but the Kenalog is far better for the more difficult times.

Yes, I suggest you check out the RLS Foundation as well. You will learn a lot and get some insights that may help guide you in the right direction. I have received good guidance from my Mayo hematologist and the Mayo sleep department. My hematologist is my go-to person for this entire scenario. Highly recommend you seek the knowledge this specialty and Mayo provide.

Blessings, Elizabeth