Treatment for Prostate Cancer Metastasized to Bones

Hi just started Russ on XTANDI lots of bad side effects Psa went up a bit ! I’m scared 😟

Xtandi didn't work for me. After 3 months I couldn't put my jacket on without help. Sore muscles. PSA rose also.

I was on Erleada and hormone medication for 13 months but I have been off of all meds now for 10 months. It worked for me but the side effects, especially sleepy and slept poorly and more were certainly present. I kept in mind that the side effects were not as severe as what I observed in a family member on chemo. I was thankful to get these meds and thankful that they worked for me but no one likes the side effects. Good Luck.

Only side effect of xtandi has been dry mouth but again I am on a Capac machine I keep a dry mouth spray by bed side and water

From reading this discussion, I realise that I'm lucky to be tolerating Erleada (Apalutamide) and Firmagon (Degarelix) relatively well. I have one bad day (flu-like symptoms) and two so-so ones after each monthly Firmagon shot, along with some swelling at the location of the shot, and every afternoon I have to lie down for an hour or two, but otherwise I don't think the meds are affecting my life nearly as much as the after-effects of the spinal-cord compression and resulting physical rehab.

I find that lightly icing the location of the Firmagon shot periodically for a couple of days helps to keep down the swelling. If you have castrate-sensitive metastatic prostate cancer, the Titan study was a pretty strong vote for continuing with ADT and Erleada if able, because both 5-year overall survival and progression-free survival (e.g. not needing chemo) were dramatically improved.

Source: https://pubmed.ncbi.nlm.nih.gov/33914595/

I have been on Lupron for 22 years. In the beginning, PSA rose a tad , but by combining the Lupron with Casodex, I was quickly in remission. Within a few months, I was off the Casodex and. have been on just Lupron ever since with little to no side effects. Hot flashes vanished long ago. Is Lupron no longer presented as an option?

My prostrate cancer once found metastasized to my bones too ( thats another story. I had 6 rounds of chemo. I'm currently on Abiraterone and Prednisone. I will start back on Zometa in about a week, this helps with the bones. I get an injection of Eligard every 3 months.
Sides effects- tiredness, muscle loss (due to testosterone removal),hot flashes and bone pain every so often. I had some issues with chemo brain but memory has returned.
Wish and hope for the best for us all

https://clinicaltrials.ucsf.edu/prostate-cancer
The discovery of CLTA-4 is changing cancer treatment including prostate cancer. Especially with metastatic prostate cancer the clinical trials are worth checking into.

Thank you -- that's very interesting. All of the references I can find for CLTA-4 with prostate cancer refer to metastatic castrate-resistant prostate cancer (e.g. your PSA is rising even with ADT). So far, mine is castrate-sensitive (ADT is keeping the PSA undetectable), but it's good to know what the next steps might be if/when ADT+Erleada stop working for me.

I'm 55. Diagnosed with PCa and mets to hip, L5 and sacrum in January 2023. I'm on abiraterone and Prednisone daily, with a lupron shot every 3 months. I get hot flashes occasionally but they are such a minor side effect for me. I don't have any side effects from the lupron shot other than the expected minor pain from the injection. My PSA was originally 359 and it's been around .11 for the past 6 months. I'm stable and generally feeling great.