I have had shots given about 6 times now with now problem, once a month. The last time it left a knot at the injection site. When I complained the next time I went in for a shot the nurse said it was a side effect of Faslodex. But I believe she did not give the shot slow enough. Of course she would never admit that. I asked if it would ever go away & she said "doubtful." Great ! Some say put ice on it some say heat. So which is it???