Hi Mike, I can appreciate your thoughts on whether the vaccinations had anything to do with the change IgM levels. However, if your numbers were elevating prior the vaccinations, basically the ball was already rolling on the changes with the plasma cell production. So it might be difficult to know if the shots had an impact and you may never know for sure. Either way, from my experience with blood conditions the end result would eventually have been the same with the proliferation. So correlation doesn’t imply causation.

A little information on M-protein
https://www.healthline.com/health/m-protein

We have a number of ongoing discussions in the forum with members who also have WM. If you haven’t already this discussion, Waldenström's Macroglobulinemia, would be a good place meet other members like @squidlee @catalinae @champ9810 @ejrquast and more who have WM.
https://connect.mayoclinic.org/discussion/waldenstrms-macroglobulinemia/
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The I.W.M.F. (International Waldenstrom’s Macroglobulinemia Foundation) would also be a great source of information for you with your newer diagnosis of WM.

Back to your flu shot…Influenza vaccinations, covid boosters, and any other vaccinations induce a protective memory immune response in the B Cells. Any vaccination that you get can trigger an immune response. That’s the goal because it then signals the body to make antibodies. So if you’re exposed to those viruses or bacteria, your immune system will have gotten a jumpstart in recognizing the invaders and can launch an attack sooner. It doesn’t guarantee a person won’t still get ill but generally the infection would be less severe. That’s why important for anyone with a blood cancer or blood condition to have a flu shot or Covid vaccination to help give the body a fighting chance by bolstering the immune system because we already have a weaker immune response to illness.

I think if your doctor gives you the go ahead that it’s something you should consider. The protection offered can be vital to continued good health.