I tried Tezspire and unfortunately fell at around the same time, not related. I experienced pretty bad back pain afterwards so cannot truthfully attribute this to Tezspire although that’s a main side effect. It helped my asthma tremendously but I stopped due to my pain. I’ve since had to get a hip replacement and will soon start Tezspire again. The side effects from Prednisone are probably worse for your body than Tezspire. You’ll never know unless you try. It was the only asthma medication that’s ever helped me. Good luck