Side effects with omeprazole/Prilosec use

Posted by blueorca @blueorca, May 5, 2018

i am an 18-year user of daily OTC Prilosec. It does a perfect job of controlling my GERD but I am constantly battling side effects of nutritional deficiencies in iron, B-12, magnesium, etc. For example, my hair is extremely thin and loss of energy is a constant problem. I am looking for specific help in knowing which supplements to take for this and in what doses and formats and on what schedule. All the nutritionists I've found locally are not well-versed in Prilosec use. Is there a medical provider out there who specializes in this? And would they be willing to work with me long distance?

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Profile picture for gigi4 @gigi4

In my experience, going off the PPI also required dietary changes. I went cold turkey since the GI who did my endoscopy told me to stop and never take again due to my cells being hypertrophic (very enlarged).
I immediately went gluten free, dairy free, sugar free (use organic stevia now), alcohol free, and switched to a low acid coffee. After 2 weeks I started feeling immensely better. Short version of my journey: After some testing, I learned I was gluten intolerant, had SIBO, a yeast infection and reacting to mold. I consulted with a nutritionist at my doctor’s office and she guided with foods to omit while my gut healed. And foods to definitely add to my diet.
Getting off a PPI can be done with the right help.
Best to you, I know it’s not easy.

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I just had my Linx removed and was back on PPI's with ulcers and stage C esophagitis. Want to get off but doctors think they are perfectly safe. Now read they cause dementia. What kind of foods can you eat? I don't eat any fructose, grains, carbs and use low acid coffee, really doesn't leave a lot of choice! Can't have fruit or most vegetables.

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Profile picture for dedhambeth @dedhambeth

I have been reading the here about the long term side effects of omeprozole and am going to try to wean off. Suggestions? Thanks!

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Hi, initially I only ate eggs and toast the majority of the time and soup until my stomach calmed down. Then I started adding food back in slowly to see how I would feel. I also found a fantastic doctor and nutritionist who helped me. I use low acid coffee as well, eat only gluten free products. If I want pasta, I buy Italian brands as European wheat is very different from US wheat. Quinoa and brown rice are digestible. I only eat fruit from the berry family the majority of the time now - strawberries, raspberries, and blueberries and avocados. Blueberries especially are very good and highly nutritious which I use in smoothies. Find a good protein powder, add almond or oat milk and about a cup of blueberries and blend, easily digested. For vegetables, I eat those considered low glycemic. I eat lots of eggs either hard boiled, scrambled with a mix of feta cheese and some greens like spinach. Also organic yogurt made with either milk or sheep/goat milk which is easily digested. There is also a yogurt that is labeled A2 which is more digestible. And then I also stick to grass fed butter, grass fed beef, wild caught fish. I choose organics as much as possible too to avoid toxins as much as possible. For a snack, I have crackers (gluten free by Simple Mills) and almond butter. Peanut butter is not good. It is highly inflammatory. The way peanuts are stored makes them moldy which creates aflatoxin - associated with increased risk of liver cancer. Start slowly adding foods so you can identify what works for you and what doesn't. If you don't exercise, try walking daily for 20 minutes. Walking helps with digestion. Eat at least 3-4 hours before bedtime. I would also encourage you to try meditation and breath work to relieve stress if you are not already doing this. Stress is a very big contributor to what happens in our gut. These are 2 meditation apps I use - Insight Timer and Headspace. Best to you finding what works.

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Profile picture for Father of sticky rice @fatherofstickyrice

10 years ago or so, I had severe symptoms of having food stuck in my esophagus and not being able to swallow or bring food back up. This put me in the hospital a few times until an endoscopy diagnosed me with a schatzki ring. My gastroenterologist nipped it in one or two places and prescribed omeprazole 20 mg once per day. This worked fine for years. My current primary care physician wants me to come off of this proton pump inhibitor (PPI) and use an H2 blocker instead. I agree. I tried about a 10-day transition alternating between the two medications and then went to the H2 blocker (Famotidine) for 3 months with no omeprazole. I had swallowing difficulty symptoms almost every meal. They were mild to severe ( inability to swallow or bring food back up for 20 minutes with a production of fluid [saliva?] which required spitting and some small amounts of food coming up). So, I went back on Omeprazole about a month ago. Now I have obtained a prescription both. I would like to try to wean myself off of the PPI and onto an H2 blocker again. Here is my plan:● Alternate omeprazole 20 mg /day early am with famotidine 20 mg before breakfast and dinner for 14 days. Then alternate with PPI every 3rd day for 14 days. Then alternate with PPI every 4th day for 14 days.Does anyone have any experience with this transition? Any suggestions.

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Going to transition to see if this will avoid heart palpitations that have started to occur after a year on nexium.

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Profile picture for gigi4 @gigi4

Hi, initially I only ate eggs and toast the majority of the time and soup until my stomach calmed down. Then I started adding food back in slowly to see how I would feel. I also found a fantastic doctor and nutritionist who helped me. I use low acid coffee as well, eat only gluten free products. If I want pasta, I buy Italian brands as European wheat is very different from US wheat. Quinoa and brown rice are digestible. I only eat fruit from the berry family the majority of the time now - strawberries, raspberries, and blueberries and avocados. Blueberries especially are very good and highly nutritious which I use in smoothies. Find a good protein powder, add almond or oat milk and about a cup of blueberries and blend, easily digested. For vegetables, I eat those considered low glycemic. I eat lots of eggs either hard boiled, scrambled with a mix of feta cheese and some greens like spinach. Also organic yogurt made with either milk or sheep/goat milk which is easily digested. There is also a yogurt that is labeled A2 which is more digestible. And then I also stick to grass fed butter, grass fed beef, wild caught fish. I choose organics as much as possible too to avoid toxins as much as possible. For a snack, I have crackers (gluten free by Simple Mills) and almond butter. Peanut butter is not good. It is highly inflammatory. The way peanuts are stored makes them moldy which creates aflatoxin - associated with increased risk of liver cancer. Start slowly adding foods so you can identify what works for you and what doesn't. If you don't exercise, try walking daily for 20 minutes. Walking helps with digestion. Eat at least 3-4 hours before bedtime. I would also encourage you to try meditation and breath work to relieve stress if you are not already doing this. Stress is a very big contributor to what happens in our gut. These are 2 meditation apps I use - Insight Timer and Headspace. Best to you finding what works.

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This is really great advice- thank you for sharing!

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Profile picture for Gary, Alumni Mentor @gman007

As a result of chronic pancreatitis and the resultant decrease in my Pancreas' ability to produce digestive enzymes, I was put on 40 mg. of omeprazole twice a day. I think I took that dose for 6-8 years and then read this: https://www.cbsnews.com/news/common-heartburn-drugs-linked-with-kidney-disease/. I always assumed there were reasons that all manufacturers of PPI's (proton pump inhibitors - Prilosec, Nexium, Prevacid) recommended that one should not take for longer than 14 days without seeing a doctor. The most immediate concern being a masking of a potentially dangerous issue with bleeding ulcers and other problems high levels of acid could cause. I stopped taking the medication cold turkey and did not experience any type of withdrawal symptoms. I occasionally take ranitidine (zantac) as it works by a different mechanism, but only when necessary. I don't know if others will experience withdrawals, but if I were determined to stop and my physician was not supportive, I would talk with my pharmacist about the best method of withdrawing.
Good luck to anyone trying to withdraw,
Gary

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Ranitidine was taken off the market, so hopefully you do not take it any longer.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I switched from omeprazole to rabeprazole instantly. Omeprazole gave me daily diarrhea. Rabeprazole works very well to control GERD, but it does give me a lot of gas. Originally I had Barrett's Esophagus, but my last endoscopy showed none.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I tried several of the brands with Omeprazole. The only one that has worked for me is Zegerid. I have been on it for years. At long as I take it every morning I’m good to go.
Tried getting off of it several times over the years but no luck.
I assume maybe it works better because of the Sodium Bicarbonate with it.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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Yes. I was on in for 25 years and had to stop abruptly/completely while in the hospital with microscopic colitis. So far so good. Was originally prescribed due to GERD.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I was on PPIs (prescribed by two doctors) for years. First to supposedly treat me for GERDS. The second time when an endoscopy showed gastritis.

Rule #1. DO NOT GO. cold turkey. You must wean yourself off any PPI gradually. Why? the PPI inhibits the pumps that make acid, because you NEED stomach acid to digest your food. BUT you body, needing that acid, keeps making more pumps, which the PPIs keep inhibiting. When you go cold turkey all the pumps come back on full blast and you get agony. I have high pain treshholds so I soldiered on but boy was it uncomfortable.

Rule #2. You have to rebuild your gut lining and your gut microbiome. For the former try zinc carnosine. For the latter, BIOGais gut health ...and lots of fiber and foods like artichoke, sun chokes and foods with inulin.

Rule #3. Try half a lemon in water first thing in the morning. Try some apple cider vinegar before bedtime (in water of course). Why? Your stomach lumen wants to be a 5.5 PH. That's slightly acidic.

Rule #4. Try to get as healthy as you can and lose weight if you need to. The ONLY way you can do that is time restricted eating or intermittent fasting as it is known. If you don't like breakfast by all means skip it. I never cared for breakfast or breakfast foods but dutiful ate it as the medical establishment and Big Brother claimed we had to. Look where that got us. An obesity epidemic. I like to feast for dinner, a great variety of nutrients and eat to satiety. I have cut way down on alcohol although I still like the occasional half glass of wine or a mezcal which I make with my own hibiscus juice, lime, orange concoction. Get and read Jason Fund Obesity Code and Diabetes Code. Do cut out any added sugars or artificial sweeteners. They are sheer poison. I managed to cure even my Insulin Resistance and have lost and kept off 41 pounds over about 4 years.

I am 85. Never healthier after bouts of awful diseases which by and large doctors only made worse. It is wonderful to feel and be healthy. Your whole outlook on life changes.

Rule #5. Read and watch good YouTube health talks (Robert Lustig, Perlmutter, Sten Ekberg, Jason Fung, Peter Attria. So much more information is available today to us than it was in the past. You also can access any studies on the HIH site or Medline. Be very skeptical about any advice given you by run of the mill Western trained docs. They get NO nutrient education and the whole system has been coopted by Big Food and Big Pharma and Federal Guidelines which are generally the very apposite of what you need to do to maintain optimal health. As an example I recently food Stevia and "natural flavors" even in supplements. Hopeless. Stevia wrecks your microbiome and raises insulin by at least 20% over ordinary glucose. Almost makes you think that "they" want to keep us all sick. Who the hell needs to have their pills sweetener? It is sheer madness.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I would like to share with you that I was taking Nexium in the morning, had a flareup (maybe from carrying something very very heavy) and so I added famotidine at night. Since I still wasn't feeling well, I decided to try to switch the Nexium to famotidine, which I did gradually. Then, taking famotidine morning and night I still was not feeling great, so I decided to not take the famotidine in the morning and instead took a probiotic on an empty stomach. I felt a bit better with this. I then started taking melatonin at night and stopped the famotidine at night. The melatonin seems to reduce the gerd, although I do still have gerd symptoms at night. So, now I'm not taking nexium nor famotidine, and I feel better than I felt before. Still not perfect, but hoping that I'm in the right direction.
So, consider if reducing medications might make you feel better. (but reducing any PPI needs to be done very gradually or you'll have an acid surge, and expect to have a few days of feeling worse, so take other meds to get you through those days)

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